DOUBLE DISSOCIATION OF FORNIX AND CAUDATE-NUCLEUS LESIONS ON ACQUISITION OF 2 WATER MAZE TASKS - FURTHER EVIDENCE FOR MULTIPLE MEMORY-SYSTEMS
DOUBLE DISSOCIATION OF FORNIX AND CAUDATE-NUCLEUS LESIONS ON ACQUISITION OF 2 WATER MAZE TASKS - FURTHER EVIDENCE FOR MULTIPLE MEMORY-SYSTEMS
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DOI：
10.1037/0735-7044.106.3.439
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发表时间：
1992-06-01
影响因子：
1.9
通讯作者：
MCGAUGH, JL
中科院分区：
文献类型：
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作者：
PACKARD, MG;MCGAUGH, JL
本研究探讨了损毁尾状核或穹隆海马伞对两种水迷宫任务习得的影响。在这两个任务中，都使用了两个不同视觉模式的橡皮球作为平台(即线索)。正确的球杆被固定在一个水下的矩形平台上，可以由动物安装在上面以逃离水。“不正确”的球杆被固定在一个薄的圆形底座上，无法安装。在空间版的任务中，在所有试验中，正确的线索都位于迷宫的同一象限，而线索上的视觉模式在不同的试验中是不同的。穹隆的损伤，而不是尾状核，损害了与对照动物有关的这一空间任务的获得。在同一视觉辨别版本的任务中，所有试验的正确线索都具有特定的视觉模式，并且正确线索的空间位置在不同的试验中是不同的。尾状核的损伤，而不是穹隆，损害了与对照动物相关的视觉辨别任务的获得。观察到的双分离支持了这样的假设，即海马体和尾状核是系统的一部分，它们所调节的记忆类型不同。
The present study examined the effect of lesions of the caudate nucleus or fimbria-fornix on the acquisition of two water maze tasks. In both tasks, two rubber balls with different visual patterns were used as platforms (i.e., cues). The "correct" cue was attached to a submerged rectangular platform and could be mounted by an animal to escape the water. The "incorrect" cue was attached to a thin round pedestal and could not be mounted. In a spatial version of the task, the correct cue was located in the same quadrant of the maze on all trials, whereas the visual pattern on the cue was varied from trial to trial. Lesions of the fornix, but not the caudate nucleus, impaired acquisition of this spatial task in relation to control animals. In a simultaneous visual discrimination version of the task, the correct cue on all trials was one with a specific visual pattern, and the spatial location of the correct cue was varied from trial to trial. Lesions of the caudate nucleus, but not the fornix, impaired acquisition of this visual discrimination task in relation to control animals. The double dissociation observed supports the hypothesis that the hippocampus and caudate nucleus are parts of systems that differ in the type of memory they mediate.