Giardia lamblia Nek1 and Nek2 kinases affect mitosis and excystation.
Giardia lamblia Nek1 and Nek2 kinases affect mitosis and excystation.
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DOI：
10.1016/j.ijpara.2012.03.001
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发表时间：
2012-04
影响因子：
4
通讯作者：
Gillin FD
中科院分区：
文献类型：
--
作者：
Smith AJ;Lauwaet T;Davids BJ;Gillin FD
The NIMA-related serine/threonine kinases (Neks) function in the cell cycle and regulate ciliary and flagellar length. The Giardia lamblia genome encodes 198 Neks, of which 56 are predicted to be active. Here we believe that we report the first functional analysis of two Giardia lamblia Neks. The GlNek1 and GlNek2 kinase domains share 57% and 43% identity to the kinase domains of human Nek1 and Nek2, respectively. Both GlNeks are active in vitro, have dynamic relocalization during the cell cycle, and are expressed throughout the life cycle, with GlNek1 being upregulated in cysts. Over-expression of inactive GlNek1 delays disassembly of the parental attachment disk and cytokinesis, while over-expression of either wild type GlNek1 or inactive mutant GlNek2 inhibits excystation.
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影响因子：
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通讯作者：
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