ANABOLIC EFFECT OF HUMAN PARATHYROID-HORMONE FRAGMENT ON TRABECULAR BONE IN INVOLUTIONAL OSTEOPOROSIS - A MULTICENTER TRIAL
ANABOLIC EFFECT OF HUMAN PARATHYROID-HORMONE FRAGMENT ON TRABECULAR BONE IN INVOLUTIONAL OSTEOPOROSIS - A MULTICENTER TRIAL
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DOI：
10.1136/bmj.280.6228.1340
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发表时间：
1980-01-01
影响因子：
105.7
通讯作者：
POTTS, JT
中科院分区：
文献类型：
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作者：
REEVE, J;MEUNIER, PJ;POTTS, JT
在基线研究后，21例骨质疏松症患者接受了人甲状旁腺激素片段（PTH 1-34）治疗，每日一次皮下注射，持续6-24个月。即使在注射后的最初几个小时内，所用剂量也未引起高钙血症。一些患者的钙和磷平衡有所改善，但组值无显著改善。然而，髂松质骨体积显著增加：通过重复盲法测量证实，平均增加比平均基线体积高70%。新骨组织学正常。新骨形成的47 Ca-动力学和组织形态计量学指数增加最多的患者显示骨小梁体积增加最多，表明人甲状旁腺激素片段治疗导致骨小梁形成和吸收率之间的分离。由于椎骨的五分之四是由松质骨组成的，这种激素片段可能被证明对治疗挤压骨折综合征患者有用。
After baseline studies, 21 patients with osteoporosis were treated with human parathyroid hormone fragment (PTH 1-34) given as once-daily subcutaneous injections for 6-24 months. The dose used did not cause hypercalcaemia even in the first few hours after injection. Calcium and phosphate balances improved in some patients, but there was no significant improvement in the group values. There were, however, substantial increases in iliac trabecular bone volume: the mean increase, confirmed by repeat blind measurements, was 70% above mean baseline volume. The new bone was histologically normal. Those patients who had the largest increases in 47Ca-kinetic and histomorphometric indices of new bone formation showed the greatest increases in trabecular bone volume, suggesting that treatment with human parathyroid hormone fragment caused a dissociation between formation and resorption rates that was confined to trabecular bone. Since vertebrae are four-fifths composed of trabecular bone, this hormone fragment may prove useful in treating patients with the crush fracture syndrome.