Differences in normal activities, job performance and symptom prevalence between patients not yet on antiretroviral therapy and patients initiating therapy in South Africa
Differences in normal activities, job performance and symptom prevalence between patients not yet on antiretroviral therapy and patients initiating therapy in South Africa
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DOI：
10.1097/01.aids.0000327634.92844.91
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发表时间：
2008-07-01
期刊：
影响因子：
3.8
通讯作者：
DeSilva, Mary Bachman
中科院分区：
文献类型：
--
作者：
Rosen, Sydney;Kethapile, Mpefe;DeSilva, Mary Bachman
目的：在资源受限的环境下，抗逆转录病毒治疗（ART）如何影响患者的经济活动尚不清楚。本研究调查了抗逆转录病毒治疗与治疗前6个月的功能损害、症状患病率和就业的关系。方法：对南非接受ART前治疗的453例患者和接受ART治疗的427例患者进行1-6个月的访谈。结果：art前受试者在之前5天工作周中报告功能受损（无法进行主要正常活动）的可能性几乎是其两倍[调整优势比（OR） 1.97；95%可信区间（Cl） 1.46-2.66]， ART前受试者的平均受损天数为1.61天，ART受试者的平均受损天数为0.87天
Objectives: Little is known about how antiretroviral therapy (ART) affects patients' economic activities in resource-constrained settings. This study examined the association of ART with functional impairment, symptom prevalence, and employment during the first 6 months on therapy.Methods: Interviews were conducted with 453 patients receiving pre-ART care and 427 patients on ART for 1-6 months in South Africa.Results: Pre-ART subjects were almost twice as likely to report being functionally impaired (unable to perform primary normal activity) in the previous 5-day work week [adjusted odds ratio (OR) 1.97; 95% confidence interval (Cl) 1.46-2.66], with a mean of 1.61 impaired days for pre-ART subjects versus 0.87 clays for ART subjects (P