The isoprostanes - Current knowledge and directions for future research
The isoprostanes - Current knowledge and directions for future research
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DOI：
10.1016/0006-2952(95)02072-1
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发表时间：
1996-01-12
影响因子：
5.8
通讯作者：
Roberts, LJ
中科院分区：
文献类型：
--
作者：
Morrow, JD;Roberts, LJ
异前列腺素是一种独特的前列腺素类化合物，在体内由游离自由基催化花生四烯酸的过氧化作用形成，不依赖于环加氧酶。这篇评论的目的是总结我们目前对异前列腺素的认识状况，并讨论我们认为进一步研究的途径。首先讨论了与异前列腺素形成的生物化学相关的新方面和分析这些化合物的方法，包括分析过程中可能出现的潜在缺陷。异前列腺素具有强大的生物活性，它们在氧化应激的某些方面的有害影响的潜在作用进行了研究。此外，有证据表明，这些生物效应可能是通过与一种独特的受体相互作用介导的。这篇评论的相当一部分涉及测量异前列腺素作为体外和体内氧化损伤标志物的效用。许多研究表明，这些化合物是氧化应激动物模型中脂质过氧化的极其准确的标记物，并阐明了氧化损伤与几种人类疾病相关的作用。最后，根据我们目前对异前列腺素的认识，提出了今后的研究方向。
The isoprostanes are a unique series of prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of arachidonic acid independent of the cyclooxygenase enzyme. The purpose of this commentary is to summarize the status of our current knowledge regarding the isoprostanes and discuss what we consider to be avenues for further research. Novel aspects related to the biochemistry of isoprostane formation and methods by which these compounds are analyzed, including potential pitfalls that may occur during analysis, are discussed first. The isoprostanes possess potent biological activity, and their potential role in mediating certain aspects of the detrimental effects of oxidant stress is then examined. In addition, evidence is presented that these biological effects may be mediated through interaction with a unique receptor. A considerable portion of this commentary deals with the utility of measuring isoprostanes as markers of oxidant injury both in vitro and in vivo. A number of studies have shown these compounds to be extremely accurate markers of lipid peroxidation in animal models of oxidative stress and have illuminated the role of oxidant injury in association with several human diseases. Finally, based upon our current knowledge of the isoprostanes, directions for future research are proposed.