Phosphine-free hydrazone-Pd complex as the catalyst precursor for a Suzuki-Miyaura reaction under mild aerobic conditions.
Phosphine-free hydrazone-Pd complex as the catalyst precursor for a Suzuki-Miyaura reaction under mild aerobic conditions.
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DOI：
10.1021/jo048107i
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发表时间：
2005-02
期刊：
影响因子：
--
通讯作者：
T. Mino;Y. Shirae;M. Sakamoto;T. Fujita
中科院分区：
文献类型：
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作者：
T. Mino;Y. Shirae;M. Sakamoto;T. Fujita
[反应：见正文] 制备并检测了乙二醛双(N-甲基-N-苯基腙) (1) 及其相关化合物，如 2-吡啶甲醛 N-甲基-N-苯基腙 (3)，作为芳基卤化物和芳基硼酸的 Suzuki-Miyaura 交叉偶联反应的配体。我们发现无膦催化剂，例如 Pd(OAc)(2)/腙配体 1 或 3，是多种底物的有效催化剂，能够以良好的产率生产偶联产物。
[reaction: see text] Glyoxal bis(N-methyl-N-phenylhydrazone) (1) and its related compounds such as 2-pyridinecarboxaldehyde N-methyl-N-phenylhydrazone (3) were prepared and examined as ligands for the Suzuki-Miyaura cross-coupling reaction of aryl halides and arylboronic acids. We found phosphine-free catalysts, such as Pd(OAc)(2)/hydrazone ligand 1 or 3, to be efficient catalysts for a variety of substrates to produce the coupling products in good yields.