Pediatric Brainstem Gliomas: An Institutional Experience.
Pediatric Brainstem Gliomas: An Institutional Experience.
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DOI：
10.4103/ajns.ajns_101_19
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发表时间：
2019-10-01
期刊：
影响因子：
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通讯作者：
Khan, Daniyal Aziz
中科院分区：
文献类型：
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作者：
Laghari, Altaf Ali;Baig, Mirza Zain;Khan, Daniyal Aziz
目的：本研究的目的是分析在我们institute.METHODOLOGY治疗的儿童脑干胶质瘤的临床资料和结果：我们回顾了18个儿童年龄组的患者在我们的机构诊断为脑干胶质瘤的文件。记录以下变量：年龄、性别、症状持续时间、诊断日期、主要临床症状、Karnofsky体能状态评分、磁共振成像结果、组织病理学结果、治疗详情、疾病进展和死亡/末次随访日期。这些数据然后被转移到SPSS 23版本，这是用于进一步analysis.Results：我们的队列的平均年龄为8.6岁（范围3-15）。男性11例（61.1%），女性7例（38.9%）。16例（88.9%）患者为弥漫性桥脑内胶质瘤（DIPG），1例（5.6%）患者为外生性髓质胶质瘤，1例（5.6%）患者为中脑/顶盖胶质瘤。平均总生存期（OS）为9.7个月。平均无进展生存期（PFS）为6.3个月。所有DIPG患者最终都死于疾病。接受放疗的DIPG患者的OS和PFS长于未接受放疗的患者（9.8和6个月vs. 3.4和2.4个月）。诊断潜伏期>1个月被发现有一个统计学显着较长的无进展interval.CONCLUSION：DIPG在儿科人群中预后不良。放射治疗有助于延长生存时间，但不能治愈。
OBJECTIVE: The aim of this study was to analyze the clinical profiles and outcomes of pediatric brainstem gliomas treated at our institute.METHODOLOGY: We reviewed the files of 18 pediatric age group patients diagnosed with brainstem glioma at our institution. The following variables were recorded: age, sex, duration of symptoms, date of diagnosis, main clinical symptoms, Karnofsky performance status score, magnetic resonance imaging findings, histopathology findings, details of the treatment given, disease progression, and date of mortality/last follow-up. This data were then transferred to SPSS version 23 which was used for further analysis.RESULTS: The mean age of our cohort was 8.6 years (range 3-15). There were 11 (61.1%) males and 7 (38.9%) females. There were 16 (88.9%) patients with diffuse intrinsic pontine gliomas (DIPGs), 1 (5.6%) patients with exophytic medullary gliomas, and 1 (5.6%) patient with midbrain/tectal glioma. Mean overall survival (OS) was 9.7 months. Mean progression-free survival (PFS) was 6.3 months. All patients with DIPG eventually passed away from their disease. Patients with DIPG who received radiotherapy had a longer OS and PFS than those who did not (9.8 and 6 months vs. 3.4 and 2.4 months). Diagnostic latency >1 month was found to have a statistically significant longer progression-free interval.CONCLUSION: DIPGs in the pediatric population have a poor prognosis. Radiotherapy serves to increase survival time but is not curative.