Dietary energy density is associated with obesity and the metabolic syndrome in US adults
Dietary energy density is associated with obesity and the metabolic syndrome in US adults
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DOI：
10.2337/dc06-2188
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发表时间：
2007-04-01
期刊：
影响因子：
16.2
通讯作者：
Christakis, Dimitri A.
中科院分区：
文献类型：
--
作者：
Mendoza, Jason A.;Drewnowski, Adam;Christakis, Dimitri A.
目的-肥胖率的上升与高能量饮食的消耗有关。我们研究了饮食能量密度是否与肥胖和相关疾病，包括胰岛素抵抗和代谢syndrome.RESEARCH设计和方法-我们进行了一项横断面研究，使用全国代表性数据的美国成年人>= 20岁，从1999年至2002年全国健康和营养检查调查（n = 9,688）。膳食能量密度仅基于食物计算。我们使用了一系列多元线性回归模型来确定膳食能量密度、肥胖指标（BMI [单位为千克每平方米]和腰围[单位为厘米]）、BMI或胰岛素血症之间的独立关联。我们使用多变量Poisson回归模型来确定膳食能量密度与代谢综合征之间的独立关联，代谢综合征由国家胆固醇和教育计划定义结果-饮食能量密度与女性较高的BMI独立且显著相关（β = 0.44 [95%CI 0.14-0.73]），男性中倾向于显著相关（β = 0.37 [-0.007至0.74]，P = 0.054）。膳食能量密度与女性（β = 1.11 [0.42-1.80]）和男性（β = 1.33 [0.46- 2.19]）的腰围较高相关。膳食能量密度也与空腹胰岛素水平升高（β = 0.65 [0.18-1.12]）和代谢综合征（患病率= 1.10 [95%CI 1.03-1.17]）独立相关。结论：膳食能量密度是美国成年人肥胖、空腹胰岛素水平升高和代谢综合征的独立预测因子。有必要进行干预研究，以降低膳食能量密度。
OBJECTIVE - Rising obesity rates have been linked to the consumption of energy-dense diets. We examined whether dietary energy density was associated with obesity and related disorders including insulin resistance and the metabolic syndrome.RESEARCH DESIGN AND METHODS - We conducted a cross-sectional study using nationally representative data of U.S. adults >= 20 years of age from the 1999-2002 National Health and Nutrition Examination Survey (n = 9,688). Dietary energy density was calculated based on foods only. We used a series of multivariate linear regression models to determine the independent association between dietary energy density, obesity measures (BMI [in kilograms per meters squared] and waist circumference [in centimeters]), glycemia, or insulinemia. We used multivariate Poisson regression models to determine the independent association between dietary energy density and the metabolic syndrome as defined by the National Cholesterol and Education Program (Adult Treatment Panel III).RESULTS - Dietary energy density was independently and significantly associated with higher BMI in women (beta = 0.44 [95% CI 0.14-0.73]) and trended toward a significant association in men (beta = 0.37 [-0.007 to 0.74], P = 0.054). Dietary energy density was associated with higher waist circumference in women (beta = 1.11 [0.42-1.80]) and men (beta = 1.33 [0.46- 2.19]). Dietary energy density was also independently associated with elevated fasting insulin (beta = 0.65 [0.18-1.12]) and the metabolic syndrome (prevalence ratio = 1.10 [95% CI 1.03-1.17]).CONCLUSIONS - Dietary energy density is an independent predictor of obesity, elevated fasting insulin levels, and the metabolic syndrome in U.S. adults. Intervention studies to reduce dietary energy density are warranted.