Cumulative number of menstrual cycles and breast cancer risk: results from the E3N cohort study of French women
Cumulative number of menstrual cycles and breast cancer risk: results from the E3N cohort study of French women
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DOI：
10.1023/a:1020684821837
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发表时间：
2002-11-01
影响因子：
2.3
通讯作者：
Clavel-Chapelon, F
中科院分区：
文献类型：
--
作者：
Clavel-Chapelon, F
目的：研究乳腺癌风险与第一次足月妊娠（FTP）前的累积周期数和寿命之间的关系，考虑初潮年龄和正常周期开始时的年龄、周期的周期性和规律性、妊娠期和哺乳期的持续时间、口服避孕药（OC）的使用和绝经年龄。方法：数据来自1990年对40-65岁妇女进行的E3 N前瞻性队列研究。在579，525人-年的随访中，共发现1718例乳腺癌病例。乳腺癌风险与首次FTP前的累积周期数之间存在高度显着的线性关系（p趋势< 0.0001）和寿命（p趋势< 0.001），两个变量的多变量相对风险（RR）大小相似。与一生周期数小于或等于402的女性相比（小于或等于30年），寿命总计为403-441、442-480、481-520和大于或等于521个周期的患者的RR为0.95（0.75-1.21）、1.21（0.97-1.52）、1.23（0.96-1.58）和1.60（1.25-2.04）。结果仅限于从未OC用户similar.Conclusions：需要进一步调查，以澄清是否的潜在因素是反复暴露于波动的激素，无排卵/排卵周期的数量，或卵泡和黄体期的相对重要性。
Objective: To examine the relationship between breast cancer risk and the cumulative number of cycles before a first full-term pregnancy (FTP) and lifetime, taking age at menarche and at onset of regular cycling, periodicity and regularity of cycles, duration of periods of pregnancy, and lactation, oral contraceptive (OC) use, and age at menopause into account.Methods: The data were taken from the E3N prospective cohort study of women aged 40-65 years in 1990. A total of 1718 breast cancer cases were identified during the 579,525 person-years of follow-up.Results: There was a highly significant linear relationship between breast cancer risk and both the cumulative number of cycles before a first FTP (p for trend < 0.0001) and lifetime (p for trend < 0.001), with multivariate relative risk (RR) of a similar magnitude for both variables. Compared to women with a lifetime number of cycles less than or equal to402 (less than or equal to30 years), the RR for those with a lifetime total of 403-441, 442-480, 481-520, and greater than or equal to521 cycles were 0.95 (0.75-1.21), 1.21 (0.97-1.52), 1.23 (0.96-1.58), and 1.60 (1.25-2.04), respectively. Results restricted to never OC users were similar.Conclusions: Further investigation is needed to clarify whether the underlying factor is repeated exposure to fluctuating hormones, the number of anovular/ovular cycles, or the relative importance of the follicular and luteal phases.