Features of optic disc progression in patients with ocular hypertension and early glaucoma.
Features of optic disc progression in patients with ocular hypertension and early glaucoma.
复制标题
DOI：
10.1097/ijg.0b013e31824c9251
复制
发表时间：
2013-06
影响因子：
2
通讯作者：
Cioffi GA
中科院分区：
文献类型：
--
作者：
Lloyd MJ;Mansberger SL;Fortune BA;Nguyen H;Torres R;Demirel S;Gardiner SK;Johnson CA;Cioffi GA
目的探讨高眼压和早期青光眼患者视盘进展的临床特点。168名高眼压或早期青光眼患者的336只眼两位青光眼专家独立地对视盘进展的基线和最新视盘照片进行分级。视盘进展定义为：新的或增加的神经视网膜边缘变薄(2小时或2小时以上)，切迹(神经视网膜边缘变薄1小时或更短)，开挖(神经视网膜边缘或视盘边缘破坏)和神经纤维层缺陷(S)。他们还确定了这些变化的地点。336只眼中有92只眼(27.4%)在中位时间6.1年后出现视盘进展。在进展者中，89%的眼睛发生了开挖，54%的人发生了边缘变薄，16%的人发生了切迹。56%(56%)的患者有两种或两种以上的进展特征。颞下象限是最常见的进展部位，但至少30%的进展眼出现一个以上的进展部位。在这组高眼压和早期青光眼患者中，视盘进展频繁发生。当评估青光眼进展的视盘时，眼科护理提供者应该特别注意增加的开挖和神经视网膜边缘变薄--特别是在颞下象限。
To determine the clinical features of optic disc progression in patients with ocular hypertension and early glaucoma. 336 eyes of 168 patients with ocular hypertension or early glaucoma Two glaucoma specialists independently graded the baseline and most recent optic disc photographs for optic disc progression. Optic disc progression was defined as: new or increased neuroretinal rim thinning (two or more clock hours), notching (one clock hour or less of thinning of the neuroretinal rim), excavation (undermining of the neuroretinal rim or disc margin), and nerve fiber layer defect(s). They also determined the location of these changes. Ninety-two of 336 eyes (27.4%) showed optic disc progression after a median of 6.1 years. Of those with progression, excavation occurred in 89% of eyes; rim thinning occurring in 54%; and notching occurring in 16%. Fifty-six percent (56%) had two or more features of progression. The inferotemporal quadrant was the most common location for progression, but more than one location of progression occurred in at least 30% of eyes with progression. Optic disc progression occurred frequently in this cohort of ocular hypertension and early glaucoma patients. When evaluating the optic disc for glaucomatous progression, eye care providers should pay particular attention to increased excavation and neuroretinal rim thinning – especially in the inferotemporal quadrant.