Time-to-Detection in Culture Predicts Risk of Mycobacterium tuberculosis Transmission: A Cohort Study
Time-to-Detection in Culture Predicts Risk of Mycobacterium tuberculosis Transmission: A Cohort Study
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DOI：
10.1093/cid/ciu244
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发表时间：
2014-07-15
影响因子：
11.8
通讯作者：
Dedicoat, Martin
中科院分区：
文献类型：
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作者：
O'Shea, Matthew K.;Koh, Gavin C. K. W.;Dedicoat, Martin
背景。接触者筛查是所有结核病控制战略的重要组成部分。我们假设液体培养中自发产生的痰样本的检测时间（TTD）可能有助于识别具有高传播风险的指示病例。我们回顾性研究了英国伯明翰的肺结核患者队列（2010年1月- 2012年12月）。我们研究了TTD与从指示病例到接触者的感染传播风险的相关性，并将其与痰液显微镜进行了比较。胸片（cxr）评分从0到6（0，无疾病的影像学证据；5，双侧空化；6，军事疾病）。在研究期间报告的184例肺结核病例中，111例纳入了最终研究，这些病例产生了825例接触者。在165名接触者中发现了传播事件（新的潜伏或活动性结核病）（传播率0.20）。短TTD (
Background. Contact screening is an essential component of all tuberculosis control strategies. We hypothesize that time-to-detection (TTD) in liquid culture of spontaneously produced sputum samples may help identify index cases at high risk of transmission.Methods. We studied retrospectively a cohort of patients with pulmonary tuberculosis in Birmingham, United Kingdom (January 2010-December 2012). We studied the correlation of TTD with the risk of transmission of infection from index cases to contacts and compared this with sputum microscopy. Chest radiographs (CXRs) were graded from 0 to 6 (0, no radiographic evidence of disease; 5, bilateral cavitation; and 6, miliary disease).Results. Of the 184 cases of pulmonary tuberculosis reported during the study period, 111 were included in the final study, and these generated 825 contacts. A transmission event (new latent or active tuberculosis) was identified in 165 contacts (transmission rate 0.20). Short TTD (