Bile acid signaling in renal water regulation
Bile acid signaling in renal water regulation
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肾水调节中的胆汁酸信号传导
DOI：
10.1152/ajprenal.00563.2018
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Wang Weidong
中科院分区：
文献类型：
--
作者：
Li Suchun;Li Chunling;Wang Weidong
新出现的证据表明，胆汁酸通过激活两种主要受体，即核法尼醇X受体（FXR）和膜G蛋白偶联胆汁酸受体-1（Gpbar 1;也称为TGR 5），在肾脏生理和疾病中发挥重要作用。FXR和TGR 5均已在人类和啮齿动物肾脏中鉴定，它们在肾脏中深度参与肾脏水处理。在小鼠中，FXR或TGR 5相关基因缺陷与水通道蛋白-2表达减少伴尿浓缩能力受损有关。在这篇简短的综述中，我们简要讨论了目前对肾脏中FXR/TGR 5信号传导的理解，特别关注集合管中胆汁酸对水通道蛋白-2表达的调节及其在疾病中的潜在意义。
Emerging evidence has shown that bile acids play important roles in renal physiology and diseases by activating two major receptors, the nuclear farnesoid X receptor (FXR) and the membrane G protein-coupled bile acid receptor-1 (Gpbar1; also known as TGR5). Both FXR and TGR5 have been identified in human and rodent kidneys, where they are deeply involved in renal water handling. In mice, FXR- or TGR5-related gene deficiency has been associated with reduced aquaporin-2 expression accompanied with impaired urinary concentration ability. In this mini-review, we briefly discuss the current understanding of FXR/TGR5 signaling in the kidneys, with a special focus on the regulation of aquaporin-2 expression by bile acids in the collecting ducts and its potential significance in disease conditions.