Neurobiological and Psychiatric Consequences of Child Abuse and Neglect
Neurobiological and Psychiatric Consequences of Child Abuse and Neglect
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DOI：
10.1002/dev.20494
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发表时间：
2010-11-01
影响因子：
2.2
通讯作者：
Nemeroff, Charles B.
中科院分区：
文献类型：
--
作者：
Heim, Christine;Shugart, Margaret;Nemeroff, Charles B.
早期生活创伤的影响及其后果的抑郁症的治疗进行了审查。早期的性虐待和身体虐待，忽视和父母的损失的患病率和临床后遗症进行了说明。临床前研究，帮助指导临床研究和实践的概述。人类临床研究的神经生物学后果的早期创伤进行了总结。调节因素，如遗传变异和性别差异，进行了讨论。少数目前的治疗结果的研究相关的这一研究领域进行了说明。指导抑郁症患者的管理和儿童虐待和忽视的历史提供。大多数经历过早期创伤经历的患者可能最好采用心理治疗和药物治疗相结合的方法进行治疗。这篇评论是专门为纪念西摩莱文谁开创了早期经验的研究领域，并在相当大的程度上启发了临床研究中所描述的这篇评论。(C)2010 Wiley Periodicals，Inc. Dev Psychobiol 52：671-690，2010.
The effects of early-life trauma and its consequences for the treatment of depression are reviewed. The prevalence and clinical sequelae of early sexual and physical abuse, neglect and parental loss are described. An overview of preclinical studies that help guide clinical research and practice is presented. Human clinical studies on the neurobiological consequences of early trauma are summarized. Moderating factors such as genetic variation and sex differences, are discussed. The few current treatment outcome studies relevant to this research area are described. Guidance for the management of patients with depression and a history of child abuse and neglect are provided. Most patients who have experienced early traumatic experiences are likely best treated with a combination of psychotherapy and pharmacotherapy. This review is dedicated to the memory of Seymour Levine who pioneered the field of early experience research and to a considerable extent inspired the clinical studies described in this review. (C) 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 671-690, 2010.