Activation of neutrophils by a novel triggering immunoglobulin-like receptor MAIR-IV
Activation of neutrophils by a novel triggering immunoglobulin-like receptor MAIR-IV
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DOI：
10.1016/j.molimm.2007.04.011
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发表时间：
2008-01-01
影响因子：
3.6
通讯作者：
Shibuya, Akira
中科院分区：
文献类型：
--
作者：
Nakano, Takako;Tahara-Hanaoka, Satoko;Shibuya, Akira
中性粒细胞在宿主防御传染性微生物病原体中发挥着核心作用。然而，其触发信号的分子基础尚未完全了解。在这里，我们展示了骨髓相关免疫球蛋白样受体（MAIR）-IV 的分子和功能特征。 MAIR-IV优先在外周血、骨髓、腹膜腔和脾脏中的中性粒细胞上表达。 MAIR-IV 与带有免疫受体酪氨酸激活基序 (ITAM) 的接头 FcR γ 链物理结合。将 MAIR-IV 与抗 MAIR-IV 单克隆抗体交联显着诱导中性粒细胞分泌促炎细胞因子 TNF-α 和 IL-6。因此，MAIR-IV可能调节中性粒细胞的激活，并在先天免疫中发挥重要作用。 (C) 2007 Elsevier Ltd. 保留所有权利。
Neutrophils play a central role in host defenses against infectious microbial pathogens. However, molecular basis for their triggering signals has been incompletely understood. Here, we show molecular and functional characteristics of myeloid- associated immunoglobulinlike receptor (MAIR)-IV. MAIR-IV was preferentially expressed on neutrophils in the peripheral blood, bone marrow, peritonea cavity and spleen. MAIR-IV physically associates with immunoreceptor tyrosine based activating motif (ITAM)-bearing adaptor FcR gamma chain. Cross-linking MAIR-IV with anti-MAIR-IV monoclonal antibody significantly induced secretion of proinflammatory cytokines TNF-alpha and IL-6 from neutrophils. Thus, MAIR-IV may regulate activation of nentrophils and play an important role for innate immunity. (C) 2007 Elsevier Ltd. All rights reserved.