High dose intravenous methylprednisolone for idiopathic myelofibrosis.
High dose intravenous methylprednisolone for idiopathic myelofibrosis.
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高剂量静脉注射甲基泼尼松龙治疗特发性骨髓纤维化。
DOI：
10.1159/000051577
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发表时间：
1988
影响因子：
6.5
通讯作者：
S. Ozsoylu
中科院分区：
文献类型：
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作者：
S. Ozsoylu
在Manoharan在1988年7月刊上关于骨髓纤维化的注释中。我找不到任何关于我们方法的评论（Ozsoylu & Ruacan, 1986; ihsoylu, 1988a）。B)这种疾病最有希望的治疗方法。除了三个孩子和一个成年人之外。b)在进行骨活检评估时，一名11岁的骨髓纤维化女孩（没有骨活检结果）于1988年2月25日开始高剂量静脉注射甲基强的松龙：每天30 mg/kg，连续3天，20 mg/kg，连续4天，然后10。每周5和2 mg/kg，然后增加1 mg/kg，直到Hb浓度达到12 g/dl。每次剂量每天1次，持续2-5分钟。她的初始Hb浓度为5。7 g/dl，堆积细胞体积20%，网织红细胞计数2.8%，白细胞计数5 × 109/l。外周血涂片含有少量正母细胞和泪滴细胞。34 d内Hb达到1.2 g/dl （PCV 37%）。最近（1988年7月15日），她每隔一天服用25mg强的松，血液学正常（血红蛋白12.9 g/dl, PCV 38%，网织网细胞计数8%，白细胞）
In the annotation by Manoharan about mylelofibrosis in the July 1988 issue of the Journal. I could not find any comment on our approach (Ozsoylu & Ruacan, 1986: ihsoylu, 1988a. b) to the treatment of this disorder which is most promising. In addition to three children and an adult (&soylu, 1988a. b) in whom bone biopsy evaluation was carried out, a n 1 l-yearold girl with myelofibrosis (without bone biopsy findings) was -started on 25 February 1988 on high dose intravenous methylprednisolone: 30 mg/kg daily for 3 d, 2 0 mg/kg for 4 d, then subsequently 1 0 . 5 and 2 mg/kg per week followed by 1 mg/kg until the Hb concentration reached 1 2 g/dl. each dose being given once a day over 2-5 min. Her initial Hb concentration was 5 .7 g/dl, packed cell volume 20%, reticulocyte count 2.8% and white blood cell count 5 x 109/l. The peripheral blood smear contained a few normoblasts and tear drop cells. Within 34 d her Hb reached 1 2 g/dl (PCV 37%). Most recently (15 July 1988) she is on 2 5 mg prednisone every other day and haematologically normal (Hb 12.9 g/dl, PCV 38%; reticulocyte count 8%, WBC