The Roles of DNA Methylation in the Stages of Cancer.
The Roles of DNA Methylation in the Stages of Cancer.
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DOI：
10.1097/ppo.0000000000000279
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Ahuja N
中科院分区：
文献类型：
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作者：
McMahon KW;Karunasena E;Ahuja N
明年将是Leslie Foulds博士概述他的假设60周年，即癌症是“一个动态的过程，通过质的不同的阶段前进”，这将导致我们对癌症进展的看法，正如我们今天所知道的那样。在过去的半个世纪里，我们对这些阶段的机制的理解一直在不断发展，并且一直在积极讨论遗传或表观遗传变化在指导这一进程中的作用。在这篇综述中，我们将重点关注一个特定的表观遗传标记- DNA甲基化-在这些不同的癌症“不连续”阶段中发挥的作用。了解这些步骤不仅可以让我们更好地了解这个迷人的生物学过程是如何运作的，还可以为针对这些恶性肿瘤的新的预后生物标志物和疗法打开大门。
Next year will mark 60 years since Dr. Leslie Foulds outlined his hypothesis that cancer is “a dynamic process advancing through stages that are qualitatively different,” leading the way to our view of cancer progression as we know it today. Our understanding of the mechanisms of these stages have been continuously evolving this past half-century and there has always been an active discussion of the roles of both genetic or epigenetic changes in directing this progression. In this review, we will focus on the roles one particular epigenetic mark - DNA methylation - plays in these various “discontinuous” stages of cancer. Understanding these steps not only gives us a better picture of how this fascinating biological process operates, but opens the doors to new prognostic biomarkers and therapies against these malignancies.