Broader autism phenotype as a risk factor for postpartum depression: Hamamatsu Birth Cohort (HBC) Study
Broader autism phenotype as a risk factor for postpartum depression: Hamamatsu Birth Cohort (HBC) Study
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DOI：
10.1016/j.rasd.2014.08.010
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发表时间：
2014-12-01
影响因子：
2.5
通讯作者：
Mori, Norio
中科院分区：
文献类型：
--
作者：
Asano, Ryosuke;Tsuchiya, Kenji J.;Mori, Norio
更广泛的自闭症表型（BAP）是指行为和认知倾向的表达，这些倾向较温和，但与定义自闭症谱系障碍的行为和认知倾向在性质上相似，可以在产后抑郁症（PPD）中发挥关键作用。我们调查了孕妇的BAP是否会增加患PPD的风险，使用日本的代表性出生队列。孕妇在妊娠中期（N = 841）入组滨松出生队列（HBC）研究，并随访至分娩后3个月。BAP主要在妊娠第二个三个月期间使用广泛表型自闭症症状量表进行测量。参与者在分娩后的前3个月内至少有一次在爱丁堡产后抑郁量表上得分为9分或更高，被诊断为PPD。在参与者中，128名（15.2%）妇女被发现患有PPD。多因素Logistic回归分析显示，BAP与PPD相关（OR = 1.19，95%CI [1.07-1.31]），即使在控制了其他潜在混杂因素后也是如此。此外，抑郁症和/或焦虑症病史（包括妊娠期间并发的抑郁和焦虑症状）也不影响这种关联。研究结果表明，患有BAP的孕妇患PPD的风险较高。(C)2014作者由Elsevier Ltd.发布。这是CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/3.0/）。
The broader autism phenotype (BAP), which refers to the expression of behavioral and cognitive propensities that are milder but qualitatively similar to those defining autism spectrum disorder, can play a crucial role in postpartum depression (PPD). We investigated whether pregnant women's BAP would increase the risk for PPD, using a representative birth cohort in Japan. Pregnant women were enrolled in the Hamamatsu Birth Cohort (HBC) Study during their mid-gestation (N = 841) and were followed up until 3 months after delivery. BAP was measured mainly during the 2nd trimester of the pregnancy by using the Broader Phenotype Autism Symptoms Scale. Participants scoring 9 points or higher on the Edinburgh Postnatal Depression Scale at least once during the first 3 months after childbirth were diagnosed with PPD. Among participants, 128 (15.2%) women were found to have PPD. Multiple logistic regression analyses showed that BAP were associated with PPD (OR = 1.19, 95% CI [1.07-1.31]), even after controlling for other potential confounders. In addition, the association was not moderated by history of depression and/or anxiety disorders, including concurrent depressive and anxiety symptoms during pregnancy. The findings suggest that pregnant women with BAP have an elevated risk for PPD. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).