Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury.
Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury.
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DOI：
10.1007/s12035-017-0503-9
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发表时间：
2018-03
影响因子：
5.1
通讯作者：
Sanderson TH
中科院分区：
文献类型：
--
作者：
Anzell AR;Maizy R;Przyklenk K;Sanderson TH
线粒体是疾病期间细胞命运的关键调节器。它们通过产生为细胞过程提供燃料的ATP来控制细胞存活，并且相反地，通过释放促凋亡因子如细胞色素C来诱导细胞凋亡来控制细胞死亡。因此，必须有严格的质量控制机制，以确保健康的线粒体网络。质量控制机制主要由线粒体动力学和线粒体自噬调节。线粒体分裂（分裂）和融合的过程允许受损的线粒体被分离，并促进线粒体组分如DNA、蛋白质和代谢物的平衡。线粒体自噬的过程负责受损线粒体的降解和再循环。这些线粒体质量控制机制已在慢性和急性病理学如帕金森病、阿尔茨海默病、中风和急性心肌梗死中得到充分研究，但对这两个过程如何相互作用并促成特定病理生理状态知之甚少。迄今为止，线粒体质量控制在急性和慢性疾病中的作用的证据是不同的，并表明线粒体质量控制过程可以根据疾病状态提供生存和死亡功能。本文综述了线粒体质量控制的分子机制，总结了我们目前对线粒体质量控制在急性与慢性疾病进展中所起的复杂作用的理解，并推测了线粒体质量控制机制的靶向操作可能被用于新的治疗干预措施的合理设计的可能性。
Mitochondria are key regulators of cell fate during disease. They control cell survival via the production of ATP that fuels cellular processes and, conversely, cell death via the induction of apoptosis through release of pro-apoptotic factors such as cytochrome C. Therefore, it is essential to have stringent quality control mechanisms to ensure a healthy mitochondrial network. Quality control mechanisms are largely regulated by mitochondrial dynamics and mitophagy. The processes of mitochondrial fission (division) and fusion allow for damaged mitochondria to be segregated and facilitate the equilibration of mitochondrial components such as DNA, proteins, and metabolites. The process of mitophagy are responsible for the degradation and recycling of damaged mitochondria. These mitochondrial quality control mechanisms have been well studied in chronic and acute pathologies such as Parkinson’s disease, Alzheimer’s disease, stroke, and acute myocardial infarction, but less is known about how these two processes interact and contribute to specific pathophysiologic states. To date, evidence for the role of mitochondrial quality control in acute and chronic disease is divergent and suggests that mitochondrial quality control processes can serve both survival and death functions depending on the disease state. This review aims to provide a synopsis of the molecular mechanisms involved in mitochondrial quality control, to summarize our current understanding of the complex role that mitochondrial quality control plays in the progression of acute vs chronic diseases and, finally, to speculate on the possibility that targeted manipulation of mitochondrial quality control mechanisms may be exploited for the rationale design of novel therapeutic interventions.
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影响因子：
5.3
作者：
Delettre, C;Griffoin, JM;Hamel, CP
通讯作者：
Hamel, CP
影响因子：
9.2
作者：
De Vos, KJ;Allan, VJ;Sheetz, MP
通讯作者：
Sheetz, MP
影响因子：
11.2
作者：
Biskup, Saskia;Moore, Darren J.;Dawson, Valina L.
通讯作者：
Dawson, Valina L.
影响因子：
14
作者：
通讯作者：
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Parkin对泛素 - 蛋白酶体系统的广泛激活对于线粒体至关重要。
影响因子：
3.5
作者：
Chan NC;Salazar AM;Pham AH;Sweredoski MJ;Kolawa NJ;Graham RL;Hess S;Chan DC
通讯作者：
Chan DC