Neurobiology of the development of motivated behaviors in adolescence: A window into a neural systems model
Neurobiology of the development of motivated behaviors in adolescence: A window into a neural systems model
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DOI：
10.1016/j.pbb.2008.12.013
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发表时间：
2009-09-01
影响因子：
3.6
通讯作者：
Andersen, Susan L.
中科院分区：
文献类型：
--
作者：
Ernst, Monique;Romeo, Russell D.;Andersen, Susan L.
适应性激励行为是成功生活的核心。相反，受干扰的动机行为是精神疾病的标志。基于大多数精神病理本质上是发展性的这一概念，理解在发展和精神病理中控制动机行为的神经机制是预防和治疗精神疾病的关键一步。这篇综述的重点是青春期，这是决定成功进入成年期的关键发育时期。我们首先提出了一个启发式的动机行为神经系统模型（三合一模型），该模型整合了神经科学理论和新兴的关于动机行为神经发育的功能神经成像工作。作为青春期的一个关键特征，社会再定向通过社会整合加工网络的平行模型的呈现而得到特别强调。虽然尚未整合在三元模型中，青春期的变化及其可能对青少年动机行为的贡献进行了回顾。同样，鉴于多巴胺系统在动机行为中的核心作用，本文从动物研究的角度讨论了该系统在青春期的变化。这篇综述揭示了关于正常发育个体动机行为的神经生物学知识的巨大差距，这使得将其转化为精神病理学只是试探性的。然而，它为未来的研究提供了明确的方向。Elsevier Inc.出版。
Adaptive motivated behaviors are at the core of a successful life. Conversely, perturbed motivated behaviors are the hallmark of psychiatric disorders. Based on the notion that most psychopathology is developmental in nature, understanding the neural mechanisms that control motivated behavior across development and in psychopathology is a critical step for preventing and treating psychiatric diseases. This review focuses on adolescence, which is the critical developmental period that determines the successful passage into adulthood. We first present a heuristic neural systems model of motivated behavior (triadic model) that integrates neuroscience theories and the emerging body of functional neuroimaging work on the neurodevelopment of motivated behavior. As a key feature of adolescence, social reorientation is particularly emphasized through the presentation of a parallel model of social integration processing network. Although not yet integrated in the triadic model, pubertal changes and their possible contribution to adolescent motivated behavior are reviewed. Similarly, given its central role in motivated actions, the dopamine system is discussed from the perspective of animal studies dedicated to changes of this system across adolescence. This review reveals vast gaps in knowledge about the neurobiology of motivated behavior in normally developing individuals, which makes the translation to psychopathology only tentative. However, it provides clear directions for future research. Published by Elsevier Inc.