[Width of radiation protective effects of indralin in comparative studies using different animal species].
[Width of radiation protective effects of indralin in comparative studies using different animal species].
复制标题
[使用不同动物物种的比较研究中吲哚林的辐射防护作用的宽度]。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
V. V. Antipov
中科院分区：
文献类型：
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作者：
M. V. Vasin;G. A. Chernov;V. V. Antipov
在小鼠、大鼠、仓鼠、豚鼠、狗和恒河猴ED50的实验中，研究了α -拟肾上腺素的辐射防护宽度。通过ED50、LD50和治疗指数（TI）： ED50/LD50进行估计。注射注射吲哚啉对小鼠的ED50为21.9 (16.2-29.4)mg/kg，豚鼠为28.8 (17.0-49.0)mg/kg，仓鼠为50.7 (42.9-59.8)mg/kg，狗为6.0 (4.3-8.3)mg/kg。同一动物indralin i.m.的TI分别为23.7（15.3-36.5）、25.6（13.7-47.4）、17.8（14.8-24.1）和31.1（20.6-47.3）。大鼠和犬的内源性p.o.的TI分别接近18.2和23.7。在相同条件下，小鼠、大鼠和狗的半胱胺TI分别为3.3（2.82 ~ 3.70）、2.1（1.57 ~ 2.82）和1.22。在大约5-10分钟内测量小鼠（100mg /kg, i.p., i.m）消除吲哚林的T50毒理学特性。在30- 60min重复施用的条件下，随着LD50升高15-30%，对有毒剂量脱敏。在放射防护作用的最佳药效学剂量下，消除吲哚啉的T50对小鼠为19.3（13.3-28.0）分钟，对仓鼠为-19.2（15.3-25.9）分钟，对大鼠为-26.9（20.4-35.5）分钟，对狗为-40.2（30.5-53.1）分钟。在从老鼠实验到狗实验的过渡过程中，消除吲哚林的T50增加了两倍并没有与充分增加放射性保护剂的毒性相结合。讨论了氨基硫醇与辐射保护剂区别的病理生理基础，通过细胞受体实现辐射保护作用的宽度。
In the experiments on mice, rats, hamsters, guinea pigs, dogs and Macaca Rhesus ED50, the width of radioprotective effect of indralin from alpha-adrenomimetics was investigated. It was made an estimate by ED50, LD50 and therapeutic index (TI): ED50/LD50. ED50 of indralin i.m. on mice is 21.9 (16.2-29.4) mg/kg, on guinea pigs --28.8 (17.0-49.0) mg/kg, on hamsters --50.7 (42.9-59.8) mg/kg and on dogs --6.0 (4.3-8.3) mg/kg. TI of indralin i.m. for same animals is correspondingly equal to 23.7 (15.3-36.5), 25.6 (13.7-47.4), 17.8 (14.8-24.1) and 31.1 (20.6-47.3). TI of indralin p.o. for rats and dogs is close to 18.2 and 23.7. Under the equal conditions TI of cystamine for mice, rats (i.p.) and dogs (i.v.) is respectively 3.3 (2.82-3.70), 2.1 (1.57-2.82) and 1.22. T50 of the elimination of indralin on mice (100 mg/kg i.p. and i.m.) for toxicologic properties measured circa 5-10 min. Under the conditions of repeated application in 30-60 min indralin desensitization to toxic doses happened as the rise of LD50 by 15-30%. T50 of the elimination of indralin in optimum doses for the pharmacodynamic of radioprotective effect is 19.3 (13.3-28.0) min on mice, --19.2 (15.3-25.9) on hamsters, --26.9 (20.4-35.5) on rats and --40.2 (30.5-53.1) min on dogs. In the transition from the experiment on mice to dogs twofold rise of T50 of the elimination of indralin doesn't combine with adequate increase the toxicity of the radioprotector. Pathophysiologic foundation of distinctions between aminothiols and radioprotector realizing the effect through cell receptor in the width of radioprotective effect is discussed.