Connecting cell polarity signals to the cytokinetic machinery in yeast and metazoan cells.
Connecting cell polarity signals to the cytokinetic machinery in yeast and metazoan cells.
复制标题
将细胞极性信号连接到酵母和后生动物细胞的细胞分裂机制。
DOI：
10.1080/15384101.2020.1864941
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Moseley,JamesB
中科院分区：
文献类型：
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作者：
Magliozzi,JosephO;Moseley,JamesB
极化生长和胞质分裂是两个基本的细胞过程，存在于几乎所有的细胞类型。材料不对称分布的机制允许细胞以极化方式生长。这产生了在所有细胞类型中可见的各种细胞形状。在分裂间期极化生长后，分裂细胞组装一个含有蛋白质机制的细胞动力学环，以压缩和分离子细胞。在这里，我们讨论了细胞极性信号通路如何作用于胞质分裂，重点是收缩性肌动球蛋白环（CAR）的直接调节。最近的研究利用磷酸化蛋白质组学来鉴定细胞极性激酶和CAR蛋白之间的新联系。现有证据表明，一些极性激酶指导CAR蛋白和结构的局部组织，同时也有助于细胞内分裂平面的全局组织。我们提供了几个例子，这种调节从芽殖酵母，裂殖酵母，和后生动物细胞。在某些情况下，激酶-底物连接指向这些不同生物体中的保守过程。我们指出了几个例子，未来的工作可以表明这些不同生物体细胞分裂过程的保守性和差异程度。
Polarized growth and cytokinesis are two fundamental cellular processes that exist in virtually all cell types. Mechanisms for asymmetric distribution of materials allow for cells to grow in a polarized manner. This gives rise to a variety of cell shapes seen throughout all cell types. Following polarized growth during interphase, dividing cells assemble a cytokinetic ring containing the protein machinery to constrict and separate daughter cells. Here, we discuss how cell polarity signaling pathways act on cytokinesis, with a focus on direct regulation of the contractile actomyosin ring (CAR). Recent studies have exploited phosphoproteomics to identify new connections between cell polarity kinases and CAR proteins. Existing evidence suggests that some polarity kinases guide the local organization of CAR proteins and structures while also contributing to global organization of the division plane within a cell. We provide several examples of this regulation from budding yeast, fission yeast, and metazoan cells. In some cases, kinase-substrate connections point to conserved processes in these different organisms. We point to several examples where future work can indicate the degree of conservation and divergence in the cell division process of these different organisms.