Osteoimmunology: Inflammatory osteolysis and regeneration of the alveolar bone
Osteoimmunology: Inflammatory osteolysis and regeneration of the alveolar bone
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DOI：
10.1111/jcpe.13056
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发表时间：
2019-06-01
影响因子：
6.7
通讯作者：
Gruber, Reinhard
中科院分区：
文献类型：
--
作者：
Gruber, Reinhard
目的骨免疫学涵盖炎症骨溶解的细胞和分子机制，最终导致牙槽骨的降解。骨免疫学还关注骨重建和再生过程中免疫细胞与骨细胞的相互作用。这篇综述的目的是提供关于骨免疫学如何影响牙槽骨健康和疾病的见解。方法采用叙事性的方法建立小鼠模型，研究炎性骨溶解的细胞和分子机制，以及免疫细胞对牙槽骨再生的影响。结果小鼠模型揭示了微生物和其他因素激活启动炎症反应的免疫细胞的分子途径。炎症引起的牙槽骨丢失伴随着骨形成的抑制。小鼠模型也表明，免疫细胞有助于炎症的消退和骨的再生，尽管专注于牙槽窝愈合的研究很少。结论考虑到骨免疫学在进化上是保守的，骨溶解通过引起牙齿丢失消除了炎症的原因。免疫细胞对骨再生的影响可能是重新启动膜内和软骨内骨形成发育机制的一种方式。
Aim Osteoimmunology covers the cellular and molecular mechanisms responsible for inflammatory osteolysis that culminates in the degradation of alveolar bone. Osteoimmunology also focuses on the interplay of immune cells with bone cells during bone remodelling and regeneration. The aim of this review was to provide insights into how osteoimmunology affects alveolar bone health and disease. Method This review is based on a narrative approach to assemble mouse models that provide insights into the cellular and molecular mechanisms causing inflammatory osteolysis and on the impact of immune cells on alveolar bone regeneration. Results Mouse models have revealed the molecular pathways by which microbial and other factors activate immune cells that initiate an inflammatory response. The inflammation-induced alveolar bone loss occurs with the concomitant suppression of bone formation. Mouse models also showed that immune cells contribute to the resolution of inflammation and bone regeneration, even though studies with a focus on alveolar socket healing are rare. Conclusions Considering that osteoimmunology is evolutionarily conserved, osteolysis removes the cause of inflammation by provoking tooth loss. The impact of immune cells on bone regeneration is presumably a way to reinitiate the developmental mechanisms of intramembranous and endochondral bone formation.