Auditory gating deficit to human voices in schizophrenia: A MEG study
Auditory gating deficit to human voices in schizophrenia: A MEG study
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DOI：
10.1016/j.schres.2009.09.003
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发表时间：
2010-03-01
影响因子：
4.5
通讯作者：
Onitsuka, Toshiaki
中科院分区：
文献类型：
--
作者：
Hirano, Yoji;Hirano, Shogo;Onitsuka, Toshiaki
背景：精神分裂症患者存在听觉门控缺陷；然而，对于P50对人类声音的听觉门控及其与临床症状的关系知之甚少。我们研究了精神分裂症患者的听觉门控功能及其与临床症状的关系。方法：记录22例精神分裂症患者和28例正常人对第一声和第二声刺激的听觉诱发脑磁图反应。观察P50m和N100m的听门控率，以及P50m-症状的相关性。结果：患者对人类声音的P50m门控率明显升高，特别是在左半球。此外，左侧P50m门控比值较高的患者幻听更严重，右侧P50m门控比值较高的患者幻听阴性症状更严重。结论：本研究提示精神分裂症患者对人声存在听觉门控缺陷，特别是在左半球，精神分裂症的幻听可能与听觉皮层对人声的感觉过载有关。(C) 2009 Elsevier B.V.版权所有
Background: Patients with schizophrenia have auditory gating deficits; however, little is known about P50 auditory gating to human voices and its association with clinical symptoms. We examined the functioning of auditory gating and its relationship with the clinical symptoms in schizophrenia.Methods: Auditory evoked magnetoencephalography responses to the first and the second voices stimuli were recorded in 22 schizophrenia patients and 28 normal control subjects. The auditory gating ratios of P50m and N100m were investigated and P50m-symptom correlations were also investigated.Results: Patients showed significantly higher P50m gating ratios to human voices specifically in the left hemisphere. Moreover, patients with higher left P50m gating ratios showed more severe auditory hallucinations, while patients with higher right P50m gating ratios showed more severe negative symptoms.Conclusions: The present Study suggests that schizophrenia patients have auditory gating deficits to human voices, specifically in the left hemisphere and auditory hallucinations of schizophrenia may be associated with sensory overload to human voices in the auditory cortex. (C) 2009 Elsevier B.V. All rights reserved.