Model for cooperative control of positional information in Drosophila by bicoid and maternal hunchback.
Model for cooperative control of positional information in Drosophila by bicoid and maternal hunchback.
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DOI：
10.1002/jez.1402710106
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
J. Reinitz;J. Reinitz;E. Mjolsness;David H. Sharp
中科院分区：
文献类型：
--
作者：
J. Reinitz;J. Reinitz;E. Mjolsness;David H. Sharp
果蝇（Drosophila melanogaster）的胚盘非常适合分析动物发育中的基本问题。其中一个问题是基因如何指定位置信息，这些信息决定了细胞在适当空间位置的发育途径（命运）。在本文中，我们提出了一个动力学模型的基因调控，明确地描述了位置信息是如何使用的胚盘。该模型被应用于分析重要的实验结果的依赖性的细胞命运的浓度的Bicoid形态。该模型表明，在推定的中间体的位置信息是由bicoid和hunchback基因的母系产品合作。
The blastoderm of the fruit fly Drosophila melanogaster is unusually well suited for analysis of fundamental questions in animal development. One such question is how genes specify the positional information which determines the developmental pathways (fate) of cells at appropriate spatial locations. In this paper we propose a dynamical model of gene regulation which explicitly describes how positional information is used in the blastoderm. The model is applied to analyze important experimental findings on the dependence of cell fate on the concentration of the Bicoid morphogen. The model shows that positional information in the presumptive middle body is cooperatively determined by maternal products of the bicoid and hunchback genes.