Transcription Factors in the Development and Pro-Allergic Function of Mast Cells.
Transcription Factors in the Development and Pro-Allergic Function of Mast Cells.
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DOI：
10.3389/falgy.2021.679121
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发表时间：
2021
影响因子：
--
通讯作者：
Kaplan MH
中科院分区：
文献类型：
--
作者：
Srivastava M;Kaplan MH
肥大细胞（MC）是位于身体粘膜组织中的造血来源的先天性免疫细胞，并且广泛地涉及过敏性炎症的发病机制。转录因子在肥大细胞响应驻留组织中遇到的各种微环境信号的发育和分化中具有关键作用。因此，了解肥大细胞通过转录因子的调节对于了解过敏性疾病的机制至关重要。在这篇综述中，我们总结了在定义的转录因子，影响整个身体和特定组织中的肥大细胞的发展，并参与响应细胞外环境的因素的进展。我们将进一步描述在过敏性炎症过程中影响肥大细胞生理学和扩张的转录因子的复杂网络，以及从脱粒到细胞因子分泌的功能。随着我们对肥大细胞异质性的了解越来越详细，特定转录因子在肥大细胞依赖性功能中的作用将可能为治疗靶向提供新的途径。
Mast cells (MCs) are innate immune cells of hematopoietic origin localized in the mucosal tissues of the body and are broadly implicated in the pathogenesis of allergic inflammation. Transcription factors have a pivotal role in the development and differentiation of mast cells in response to various microenvironmental signals encountered in the resident tissues. Understanding the regulation of mast cells by transcription factors is therefore vital for mechanistic insights into allergic diseases. In this review we summarize advances in defining the transcription factors that impact the development of mast cells throughout the body and in specific tissues, and factors that are involved in responding to the extracellular milieu. We will further describe the complex networks of transcription factors that impact mast cell physiology and expansion during allergic inflammation and functions from degranulation to cytokine secretion. As our understanding of the heterogeneity of mast cells becomes more detailed, the contribution of specific transcription factors in mast cell-dependent functions will potentially offer new pathways for therapeutic targeting.
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影响因子：
5.4
作者：
Andrade, Marcus V.;Iwaki, Shoko;Ropert, Catherine;Gazzinelli, Ricardo T.;Cunha-Melo, Jose R.;Beaven, Michael A.
通讯作者：
Beaven, Michael A.
影响因子：
4.3
作者：
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通讯作者：
Arnheiter H
DOI：
10.1073/pnas.1608520113
发表时间：
2016-12-06
影响因子：
11.1
作者：
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通讯作者：
Metcalfe, Dean D.
影响因子：
11.4
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通讯作者：
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影响因子：
4.4
作者：
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通讯作者：
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