FTSZ REGULATES FREQUENCY OF CELL-DIVISION IN ESCHERICHIA-COLI
FTSZ REGULATES FREQUENCY OF CELL-DIVISION IN ESCHERICHIA-COLI
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DOI：
10.1128/jb.172.5.2765-2768.1990
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发表时间：
1990-05-01
影响因子：
3.2
通讯作者：
LUTKENHAUS, J
中科院分区：
文献类型：
--
作者：
BI, E;LUTKENHAUS, J
细胞分裂受到调节，每个细胞周期仅发生一次。在大肠杆菌（一种杆状细菌）中，分裂通常发生在细胞长轴的中心；然而，在小细胞突变体中，分裂也可以在细胞极发生。这种分裂是以正常分裂为代价的，导致有核细胞长度总体增加。我们在此报告，增加 FtsZ 水平可以通过增加细胞分裂事件发生的频率来完全抑制小细胞突变体的细胞长度增加。该结果表明 FtsZ 水平控制大肠杆菌中细胞分裂的频率。
Cell division is regulated so that it occurs only once per cell cycle. In Escherichia coli, a rod-shaped bacterium, division normally takes place at the center of the long axis of the cell; however, in the minicell mutant, division can also take place at the cell pole. Such divisions take place at the expense of normal divisions, resulting in an overall increase in nucleated cell length. We report here that increasing the level of FtsZ can completely suppress the cell length increase of the minicell mutant by increasing the frequency at which cell division events tak place. This result suggest that the level of FtsZ controls the frequency of cell division in E. coli.