PROLIFERATIVE EVENTS IN THE CEREBRAL VENTRICULAR ZONE
PROLIFERATIVE EVENTS IN THE CEREBRAL VENTRICULAR ZONE
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DOI：
10.1016/0387-7604(95)00029-b
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发表时间：
1995-05-01
影响因子：
1.7
通讯作者：
TAKAHASHI, T
中科院分区：
文献类型：
--
作者：
CAVINESS, VS;TAKAHASHI, T
新皮质的大小和复杂性差异很大，但其细胞学、层状结构和细胞结构组织的总体方案在哺乳动物物种中是非常相似的，这些结构和组织的相似之处出现在非常相似的发育历史过程中，因此，所有物种的新皮质都是在一个离散的神经元发生间隔(NI)的过程中产生的，这些新皮质是由位于发育中的脑壁边缘的假复层脑室上皮(PVE)产生的，一旦它们在该上皮中的末端细胞分裂完成，年轻的神经元就穿过脑壁迁移到新皮质，在那里它们生长、分化并成为突触结合到大脑系统中。形成最深皮质层的神经元是最早形成的，而逐渐形成的神经元是在发育的逐渐较晚的时候出现的。在小鼠的实验中，我们确定了在NI过程中出现的总细胞周期数与细胞周期输出函数Q的关系，细胞周期输出函数Q对NI的持续时间和神经元的产生速度有调节作用。细胞周期数似乎在很大程度上受G(1)期长度的进展调节。我们认为，细胞周期数的调节是由细胞外部物质介导的，作用于G(1)期的增殖细胞。
The neocortex varies vastly in size and complexity yet its cytology, laminar architecture, and general plan of cytoarchitectonic organization are closely similar across mammalian species, These similarities of structure and organization emerge in the course of a closely similarly developmental history, Thus, the neocortex in all species arises in the course of a discrete neuronogenetic interval (NI) from a pseudostratified ventricular epithelium (PVE) located at the margin of the developing cerebral wall, Once their terminal cell division in this epithelium has been completed the young neurons migrate across the cerebral wall to the neocortex where they grow, differentiate, and become synaptically incorporated into cerebral neural systems, The neurons forming the deepest cortical layers are the earliest to be formed while progressively later formed neurons arise at progressively later times in development, In experiments in mice, we have determined that it is the relation of total cell cycle number, occurring in the course of the NI, to the cell cycle output function, Q, which is regulatory to the duration of NI and to the rate of neuron production, Cell cycle number appears largely to be regulated by progression in the length of the G(1) phase of the cycle, We propose that regulation is mediated by cell external substances, acting upon the proliferating cell during G(1) phase.