Needle-free jet injection of DNA and protein vaccine of the far-eastern subtype of tick-borne encephalitis virus induces protective immunity in mice
Needle-free jet injection of DNA and protein vaccine of the far-eastern subtype of tick-borne encephalitis virus induces protective immunity in mice
复制标题
无针喷射蜱传脑炎病毒远东亚型DNA和蛋白疫苗诱导小鼠保护性免疫
DOI：
10.1111/j.1348-0421.2011.00389.x
复制
发表时间：
2011
影响因子：
2.6
通讯作者：
et al.
中科院分区：
文献类型：
--
作者：
Omori-Urabe Y;et al.
壁虱传播的脑炎病毒(TBEV)会引起人类的严重脑炎。它在日本的一个地区流行；然而，该国没有商业疫苗可用。在这项总部位于日本的研究中，通过无针注射器注射的TBEV亚病毒颗粒(SP)作为候选疫苗进行了疗效评估。用无针注射器接种编码SP的DNA比用针头和注射器注射更有效地产生中和抗体，用无针注射器接种一剂疫苗的小鼠在致死剂量的TBEV攻击下存活。这些结果表明，无针注射器接种的SP疫苗可以预防TBEV感染。
Tick‐borne encephalitis virus (TBEV) causes severe encephalitis in humans. It is endemic in one area of Japan; however no commercial vaccine is available in that country. In this Japan‐based study, the efficacy of subviral particles (SPs) of TBEV administered by needle‐free injector was evaluated as a vaccine candidate. Inoculation with SP‐encoding DNA by needle‐free injector induced neutralizing antibodies more efficiently than when administered by needle and syringe, and mice vaccinated with one dose by needle‐free injector survived challenge with a lethal dose of TBEV. These results suggest that SP vaccines delivered by needle‐free injector can protect against TBEV infection.