A pilot survey for Fusarium mycotoxin biomarkers in women from Golestan, northern Iran
A pilot survey for Fusarium mycotoxin biomarkers in women from Golestan, northern Iran
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对伊朗北部古勒斯坦妇女的镰刀菌毒素生物标志物进行试点调查
DOI：
10.3920/wmj2011.1337
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发表时间：
2012
影响因子：
2
通讯作者：
F. Islami
中科院分区：
文献类型：
--
作者：
P. Turner;Y. Gong;A. Pourshams;E. Jafari;M. Routledge;R. Malekzadeh;C. Wild;P. Boffetta;F. Islami
镰刀菌毒素是世界上许多地区常见的谷物污染物，也是各种急慢性人类疾病的危险因素。迄今为止，缺乏暴露工具限制了对潜在健康影响的流行病学研究。最近建立的脱氧雪腐镰刀菌烯醇(DON)和伏马菌素的暴露生物标记物现已可用，这里对来自伊朗北部戈莱斯坦的110名妇女(年龄在39岁至72岁)进行了试点生物标记物调查，调查对象是2007年8月至9月期间的某个时间点收集的样本。尿DON和DON-GU联合检测频率高(79/110，72%)，平均1.3 ng DON/ml尿，未检出范围(ND)-6.5 ng/ml，调整后肌酐水平平均1.5 ng DON/mg肌酐，范围ND-7.1 ng/mg)。尿脱环氧DON(DOM-1)和DOM-1葡萄糖醛酸脂联合检测，也未检测到伏马菌素B1。这项研究是该地区首次报道的基于生物标记物的DON和伏马菌素暴露评估。总体而言，目前的DON曝光率...
Fusarium mycotoxins are frequent contaminants of cereals in many world regions, and are suggested risk factors for various acute and chronic human diseases. To date a lack of exposure tools has restricted epidemiological studies of the potential health effects. Recently established exposure biomarkers for deoxynivalenol (DON) and fumonisins are now available and here a pilot biomarker survey of 110 women (aged 39 to 72 years) from Golestan, northern Iran was conducted on samples collected at one time point during August-September 2007. Urinary DON and DON-glucuronide combined were detected frequently (79/110, 72%), mean 1.3 ng DON/ml urine, range not detected (nd)-6.5 ng/ml; mean creatinine adjusted levels were 1.5 ng DON/mg creatinine, range nd-7.1 ng/mg). Neither urinary de-epoxy DON (DOM-1) and DOM-1 glucuronide combined, nor urinary fumonisin B1 were detected. This study is the first reported biomarker based exposure assessment of DON and fumonisins in this region. Overall DON exposure at this time po...