Structural basis of ventricular stiffness.
Structural basis of ventricular stiffness.
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发表时间：
1981
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通讯作者：
Thomas K. Borg;Ranson Wf;F. Moslehy;James B. Caulfield
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作者：
Thomas K. Borg;Ranson Wf;F. Moslehy;James B. Caulfield
心室僵硬度的形态学成分尚未明确界定。该刚度因子随扩张程度在宽范围内变化，在低体积时非常低，在高体积时非常高。在大鼠和仓鼠中，从30日龄到17个月，其变化不超过20%，质量增加4倍。仅这些参数就表明了一个或多个复杂结构。在所有年龄段，大鼠的心室僵硬系数约为仓鼠的两倍。这两个物种的正常心脏硬度的自然发生的变化提供了一个很好的模型，以检查可能解释两个心室硬度变化的形态学差异。通过光学显微镜、扫描和透射电子显微镜检查每个物种1至7月龄的心脏。这两个物种之间的主要差异在于120- 150-nm形式的胶原蛋白量。直径束形成围绕肌细胞群的编织物。该系统在大鼠中的分布远比仓鼠广泛，并且是唯一可以很容易地解释两个物种之间刚度差异的形态学差异。
The morphologic component of ventricular stiffness has not been clearly delineated. This stiffness factor varies over wide ranges with the degree of distension, being very low at low volumes and very high at high volumes. It is constant in rats and hamsters from 30 days of age to 17 months, varying no more than 20%, with increases in mass of 4-fold. These parameters alone suggest a complex structure or structures. The ventricular stiffness factor of rats is about twice that of hamsters at all ages. This naturally occurring variation in stiffness of normal hearts from the two species provides an excellent model to examine for morphologic differences that might explain the variation in stiffness of the two ventricles. Hearts from each species from 1 to 7 months of age were examined by light microscopy and scanning and transmission electron microscopy. There is a major difference between the two species in the amount of collagen in the form of 120- to 150-nm. diameter bundles that form a weave around groups of myocytes. This system is far more extensive in rats than hamsters and is the only morphologic difference that can easily explain the divergence in stiffness between the two species.