Innate immune defense system of the skin
Innate immune defense system of the skin
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DOI：
10.1111/j.1365-3164.2012.01082.x
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发表时间：
2013-02-01
影响因子：
1.4
通讯作者：
Gallo, Richard L.
中科院分区：
文献类型：
--
作者：
Afshar, Maryam;Gallo, Richard L.
背景抗菌肽（AMP）在皮肤先天免疫中发挥着关键作用。它们存在于许多动物（包括哺乳动物）的皮肤中，并且既是组成性存在的，又是通过感染和损伤诱导的。功能 抗菌肽对细菌、病毒、真菌和寄生虫表现出抗菌活性，其效力取决于其肽结构。它们还充当多功能效应分子，影响多种细胞过程，包括细胞迁移、增殖和分化、细胞因子产生、血管生成和伤口愈合。 AMP 产生受到抑制与微生物损伤的易感性增加和特应性皮炎的发病机制有关。这篇综述重点介绍了最近对健康和患病皮肤中 AMP（特别是 AMP 抗菌肽和 β-防御素）的表达和作用的观察结果。
Background Antimicrobial peptides (AMPs) have a pivotal role in cutaneous innate immunity. They are present in the skin of many animals, including mammals, and are both constitutively present and inducible by infection and injury. Functions Antimicrobial peptides exhibit antimicrobial activity against bacteria, viruses, fungi and parasites, with different potencies depending on their peptide structure. They also act as multifunctional effector molecules that influence diverse cellular processes, including cell migration, proliferation and differentiation, cytokine production, angiogenesis and wound healing. Suppressed AMP production has been associated with increased susceptibility to microbial insults and the pathogenesis of atopic dermatitis. This review highlights recent observations on the expression and role of AMPs, particularly the AMPs cathelicidin and beta-defensin, in healthy and diseased skin.