Disrupting cannabinoid receptor interacting protein 1 rescues cognitive flexibility in long-term estrogen-deprived female mice
Disrupting cannabinoid receptor interacting protein 1 rescues cognitive flexibility in long-term estrogen-deprived female mice
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DOI：
10.1016/j.nicl.2020.102249
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Kun Zhang
中科院分区：
文献类型：
--
作者：
Fu Yang;Yu-Jia Zhao;Si-Jie Chen;Ya-Ru Li;Pei-Yue Yang;Jing-Yu Qi;Xin-Shang Wang;Min Wang;Xu-Bo Li;Ban Feng;Yu-Mei Wu;Shui-Bing Liu;Kun Zhang
Hormone therapy (HT) has failed to improve learning and memory in postmenopausal women according to .recent clinical studies; however, the reason for failure of HT in improving cognitive performance is unknown. In .our research, we found cognitive flexibility was improved by 17 β -Estradiol (E2) in mice 1 week after ovariectomy .(OVXST), but not in mice 3 months after ovariectomy (OVXLT). Isobaric tags for relative and absolute quantitation .(iTRAQ) revealed increased cannabinoid receptor interacting protein 1 (CNRIP1) in E2-treated OVXLT mice .compared with E2-treated OVXST mice. Adeno-associated virus 2/9 (AAV2/9) delivery of Cnrip1 short-hairpin .small interfering RNA (Cnrip1-shRNA) rescued the impaired cognitive flexibility in E2 treated OVXLT mice. .This effect is dependent on CB1 function, which could be blocked by AM251 — a CB1 antagonist. Our results .indicated a new method to increasing cognitive flexibility in women receiving HT by disrupting CNRIP1.
