Reconfigurable task-dependent functional coupling modes cluster around a core functional architecture
Reconfigurable task-dependent functional coupling modes cluster around a core functional architecture
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DOI：
10.1098/rstb.2013.0526
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发表时间：
2014-10-05
影响因子：
6.3
通讯作者：
Buckner, Randy L.
中科院分区：
文献类型：
--
作者：
Krienen, Fenna M.;Yeo, B. T. Thomas;Buckner, Randy L.
分布式大脑区域之间的功能耦合随着任务环境的不同而变化，但也有稳定的特征。为了更好地了解网络配置的范围和中心趋势，使用功能 MRI (fMRI) 探索了 14 种不同的连续执行的任务状态（从被动固定到要求越来越高的分类任务）的耦合模式。任务状态之间皮层的平均全局相关性分布范围为 0.69 到 0.82。来自被动固定和分类任务的网络配置类似地预测了根据文献荟萃分析估计的任务共激活模式。因此，即使在明显不同的任务状态中，中心趋势也主导着耦合配置。除了这些共享组件之外，不同的任务状态在响应不同需求的耦合模式方面也表现出显着差异。一种可能性是，解剖连接提供了约束，充当吸引子，将网络配置拉向有限数量的鲁棒状态。可重构耦合模式的出现是对核心功能架构的重大修改。
Functional coupling across distributed brain regions varies across task contexts, yet there are stable features. To better understand the range and central tendencies of network configurations, coupling patterns were explored using functional MRI (fMRI) across 14 distinct continuously performed task states ranging from passive fixation to increasingly demanding classification tasks. Mean global correlation profiles across the cortex ranged from 0.69 to 0.82 between task states. Network configurations from both passive fixation and classification tasks similarly predicted task coactivation patterns estimated from meta-analysis of the literature. Thus, even across markedly different task states, central tendencies dominate the coupling configurations. Beyond these shared components, distinct task states displayed significant differences in coupling patterns in response to their varied demands. One possibility is that anatomical connectivity provides constraints that act as attractors pulling network configurations towards a limited number of robust states. Reconfigurable coupling modes emerge as significant modifications to a core functional architecture.