Molecular profiles of small cell lung cancer subtypes: therapeutic implications.
Molecular profiles of small cell lung cancer subtypes: therapeutic implications.
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DOI：
10.1016/j.omto.2021.02.004
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发表时间：
2021-03-26
期刊：
影响因子：
--
通讯作者：
Dome B
中科院分区：
文献类型：
--
作者：
Schwendenwein A;Megyesfalvi Z;Barany N;Valko Z;Bugyik E;Lang C;Ferencz B;Paku S;Lantos A;Fillinger J;Rezeli M;Marko-Varga G;Bogos K;Galffy G;Renyi-Vamos F;Hoda MA;Klepetko W;Hoetzenecker K;Laszlo V;Dome B
小细胞肺癌(SCLC，约占所有肺癌的13%-15%)是一种特别致命的恶性肿瘤，其特点是倍增时间快，转移倾向高。与其他类型肺癌日益个性化的治疗相比，小细胞肺癌仍然被视为一种同质性疾病，小细胞肺癌患者的预后仍然很差。然而，最近，我们对小细胞肺癌生物学的理解取得了实质性的进展。基因组学的进步和新的临床前模型的发展促进了对这种疾病的瘤内异质性和特定的基因改变的深入了解。世界范围内对小细胞肺癌研究的复苏最终导致了新的亚型特异性分类的发展，主要基于小细胞肺癌的神经内分泌特征和独特的分子特征。重要的是，这些生物学上截然不同的亚型可能定义了独特的治疗脆弱性。在这里，我们总结了目前关于小细胞肺癌亚型的分子图谱的知识，重点是它们潜在的临床意义。小细胞肺癌仍被认为是一种预后较差的同质性疾病。然而，最近的分析导致了新的亚型特异性分类的发展，主要基于神经内分泌特征和分子图谱。更好地了解这些生物学上不同的亚型可能有助于确定独特的治疗脆弱性。
Small cell lung cancer (SCLC; accounting for approximately 13%–15% of all lung cancers) is an exceptionally lethal malignancy characterized by rapid doubling time and high propensity to metastasize. In contrast to the increasingly personalized therapies in other types of lung cancer, SCLC is still regarded as a homogeneous disease and the prognosis of SCLC patients remains poor. Recently, however, substantial progress has been made in our understanding of SCLC biology. Advances in genomics and development of new preclinical models have facilitated insights into the intratumoral heterogeneity and specific genetic alterations of this disease. This worldwide resurgence of studies on SCLC has ultimately led to the development of novel subtype-specific classifications primarily based on the neuroendocrine features and distinct molecular profiles of SCLC. Importantly, these biologically distinct subtypes might define unique therapeutic vulnerabilities. Herein, we summarize the current knowledge on the molecular profiles of SCLC subtypes with a focus on their potential clinical implications. Small cell lung cancer is still regarded as a homogeneous disease associated with poor prognosis. Recent analysis, however, has led to the development of novel subtype-specific classifications primarily based on the neuroendocrine features and molecular profiles. The better understanding of these biologically distinct subtypes might help to define unique therapeutic vulnerabilities.
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影响因子：
8.8
作者：
Borromeo MD;Savage TK;Kollipara RK;He M;Augustyn A;Osborne JK;Girard L;Minna JD;Gazdar AF;Cobb MH;Johnson JE
通讯作者：
Johnson JE
影响因子：
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作者：
Carter, Brett W.;Glisson, Bonnie S.;Erasmus, Jeremy J.
通讯作者：
Erasmus, Jeremy J.
影响因子：
158.5
作者：
Aupérin, A;Arriagada, R;Aisner, J
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Aisner, J
影响因子：
51.1
作者：
Antonia, Scott J.;Lopez-Martin, Jose A.;Calvo, Emiliano
通讯作者：
Calvo, Emiliano
DOI：
10.1126/science.aag0299
发表时间：
2016-11-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Alexandrov LB;Ju YS;Haase K;Van Loo P;Martincorena I;Nik-Zainal S;Totoki Y;Fujimoto A;Nakagawa H;Shibata T;Campbell PJ;Vineis P;Phillips DH;Stratton MR
通讯作者：
Stratton MR