Early Diagnoses of Autism Spectrum Disorders in Massachusetts Birth Cohorts, 2001-2005
Early Diagnoses of Autism Spectrum Disorders in Massachusetts Birth Cohorts, 2001-2005
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DOI：
10.1542/peds.2010-2943
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发表时间：
2011-06-01
期刊：
影响因子：
8
通讯作者：
Smith, Lauren A.
中科院分区：
文献类型：
--
作者：
Manning, Susan E.;Davin, Carol A.;Smith, Lauren A.
目的：我们调查了36个月大的自闭症谱系障碍的诊断趋势(早期诊断)，并确定了与早期诊断相关的特征。方法：将马萨诸塞州的出生证明和早期干预计划数据联系起来，以确定2001年至2005年出生的婴儿在36个月之前(至2008年12月31日)登记参加早期干预并接受自闭症相关服务的婴儿。使用Cochran-Armitage趋势测试检查早期自闭症谱系障碍的趋势。CHI(2)统计被用来比较患有和不患有自闭症谱系障碍儿童的选定特征的分布。多因素Logistic回归分析确定早期诊断的独立预测因素。结果：共有3013名儿童(每10,000名研究人口出生中有77.5名)在36个月前参加了自闭症谱系障碍的早期干预。自闭症谱系障碍的发病率从2001年出生队列中的每10 000名婴儿中有56名上升到2005年的每10 000名婴儿中有93名。年龄在24岁以下、主要语言不是英语或出生在外国的母亲的婴儿早期被诊断为自闭症谱系障碍的几率较低。母亲年龄超过30岁与早期自闭症谱系障碍诊断的几率增加有关。男孩患早期自闭症谱系障碍的几率是女孩的4.5倍(95%可信区间：4.1-5.0)。结论：马萨诸塞州早期自闭症谱系障碍的诊断正在增加，这反映了在年龄较大的儿童中观察到的全国性趋势。将早期干预计划数据与基于人口的生命统计数据联系起来，对于监测自闭症谱系障碍趋势以及规划发展和教育服务需求是有价值的。儿科2011；127：1043-1051
OBJECTIVE: We examined trends in autism spectrum disorder diagnoses by age 36 months (early diagnoses) and identified characteristics associated with early diagnoses.METHODS: Massachusetts birth certificate and early-intervention program data were linked to identify infants born between 2001 and 2005 who were enrolled in early intervention and receiving autism-related services before age 36 months (through December 31, 2008). Trends in early autism spectrum disorders were examined using Cochran-Armitage trend tests. chi(2) Statistics were used to compare distributions of selected characteristics for children with and without autism spectrum disorders. Multivariate logistic regression analyses were conducted to identify independent predictors of early diagnoses.RESULTS: A total of 3013 children (77.5 per 10 000 study population births) were enrolled in early intervention for autism spectrum disorder by age 36 months. Autism spectrum disorder incidence increased from 56 per 10 000 infants among the 2001 birth cohort to 93 per 10 000 infants in 2005. Infants of mothers younger than 24 years of age, whose primary language was not English or who were foreign-born had lower odds of an early autism spectrum disorder diagnosis. Maternal age older than 30 years was associated with increased odds of an early autism spectrum disorder diagnosis. Odds of early autism spectrum disorders were 4.5 (95% confidence interval: 4.1-5.0) times higher for boys than girls.CONCLUSIONS: Early autism spectrum disorder diagnoses are increasing in Massachusetts, reflecting the national trend observed among older children. Linkage of early-intervention program data with population-based vital statistics is valuable for monitoring autism spectrum disorder trends and planning developmental and educational service needs. Pediatrics 2011; 127:1043-1051