Network motifs are enriched with transcription factors whose transcripts have short half-lives
Network motifs are enriched with transcription factors whose transcripts have short half-lives
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DOI：
10.1016/j.tig.2005.06.013
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发表时间：
2005-09-01
影响因子：
11.4
通讯作者：
Purisima, E
中科院分区：
文献类型：
--
作者：
Wang, E;Purisima, E
由于基因组中基因与转录因子（TF）的比例很大，网络基序（网络中重复出现的调节结构模式）可以自组织产生网络。我们发现一个共同的设计原则，这些图案：转录本的半衰期短显着丰富的图案和枢纽。这种丰富成为网络无标度拓扑出现的驱动力之一，使网络能够快速适应环境变化并减轻基因表达波动。基序被分类为优先用于不同细胞条件的亚型。
Network motifs, the recurring regulatory structural patterns in networks, can self-organize to produce networks because of the large ratio of genes to transcription factors (TFs) in genomes. We find a common design principle of these motifs: the TFs whose transcripts have short half-lives are significantly enriched in motifs and hubs. This enrichment becomes one of the driving forces for the emergence of the network scale-free topology, enables the network to adapt quickly to environmental changes and mitigates gene expression fluctuations. Motifs are classified into subtypes that are preferentially used in different cellular conditions.