Relationship between exhaled NO, respiratory symptoms, lung function, bronchial hyperresponsiveness, and blood eosinophilia in school children
Relationship between exhaled NO, respiratory symptoms, lung function, bronchial hyperresponsiveness, and blood eosinophilia in school children
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DOI：
10.1136/thorax.58.3.242
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发表时间：
2003-03-01
期刊：
影响因子：
10
通讯作者：
van Amsterdam, JGC
中科院分区：
文献类型：
--
作者：
Steerenberg, PA;Janssen, NAH;van Amsterdam, JGC
背景：呼出的一氧化氮(ENO)可能是一种无创的呼吸道炎症标志物，但其与其他常用指标的关系尚未得到评估。方法：对居住在高速公路附近不同城市的2504名学龄儿童中的450名7-12岁儿童的eNO水平进行测定。本研究的目的是通过皮肤点刺试验，探讨特应症患儿和非特应症患儿肺功能损害(PEF、FVC、FEV1、MMEF)、支气管高反应性(BHR)、血嗜酸性粒细胞增多与ENO水平的关系。结果：回归分析显示，过去12个月发生的喘息、流鼻水和结膜炎与ENO水平呈正相关(相对增加分别为1.48和1.41，P
Background: Exhaled nitric oxide (eNO) may serve as a non-invasive marker of airway inflammation but its relationship with other commonly used measures has not been evaluated.Methods: Levels of eNO in a sample of 450 children aged 7-12 years out of a total sample of 2504 school children living in different urban areas near motorways were determined. The aim of this cross-sectional study was to explore the relationship between eNO, impairment of lung function (PEF, FVC, FEV1 and MMEF), bronchial hyperresponsiveness (BHR), and blood eosinophilia in children with and without atopy as assessed by skin prick testing.Results: Regression analysis showed that wheezing and nasal discharge and conjunctivitis that had occurred during the previous 12 months were positively associated with eNO levels in atopic children (relative increase of 1.48 and 1.41, respectively; p