Bidirectional Crosstalk Between Neutrophils and Adipocytes Promotes Adipose Tissue Inflammation
Bidirectional Crosstalk Between Neutrophils and Adipocytes Promotes Adipose Tissue Inflammation
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中性粒细胞和脂肪细胞之间的双向串扰促进脂肪组织炎症
DOI：
10.1096/fj.201900477rr
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Takatsu K.
中科院分区：
文献类型：
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作者：
Watanabe Y;Nagai Y;Honda H;Okamoto N;Yanagibashi T;Ogasawara M;Yamamoto S;Imamura R;Takasaki I;Hara H;Sasahara M;Arita M;Hida S;Taniguchi S;Suda T;Takatsu K.
已充分证明了代谢紊乱时脂肪组织中IL-1β系统的慢性激活。然而，其在组织中的表达和激活的机制尚未探索。在这里，我们证明了IL-1β转录物在瘦小鼠白色脂肪组织（WAT）的中性粒细胞中富集。中性粒细胞与脂肪细胞的相互作用通过NF-κB途径诱导IL-1β的表达。在WAT中，脂肪细胞的脂解作用先于巨噬细胞积累中性粒细胞，并通过炎性体途径产生高水平的IL-1β。WAT中的白三烯B4（LTB 4）产生也有助于中性粒细胞蓄积。此外，LTB 4-炎性体轴有助于参与高脂饮食诱导的巨噬细胞浸润到WAT中的趋化分子的表达。我们已经确定了中性粒细胞在脂肪组织炎症发展中以前未被重视的作用：强大的IL-1β产生和巨噬细胞浸润以启动慢性炎症。Watanabe，Y.，日本，永井，Y.，本田，H.，Okamoto，N.，Yanagibashi，T.，Ogasawara，M.，Yamamoto，S.，今村河，高崎，哈拉，H.，Sasahara，M.，Arita，M.，希达，S.，Taniguchi，S.，苏达，T.，Takatsu，K.中性粒细胞和脂肪细胞之间的双向串扰促进脂肪组织炎症。FASEB J. 33，11821 - 11835（2019）。www.fasebj.org
Chronic activation of the IL‐1β system in adipose tissue on metabolic disorders is well demonstrated. However, a mechanism for its expression and activation in the tissue has remained unexplored. Here, we demonstrate that IL‐1β transcript was enriched in neutrophils of white adipose tissue (WAT) from lean mice. Mechanistically, the interaction of neutrophils with adipocytes induced IL‐1β expressionviaNF‐κB pathway. Lipolysis of adipocytes accumulated neutrophils prior to macrophages in WAT and produced high levels of IL‐1βviaan inflammasome pathway. Leukotriene B4(LTB4) production in WAT also contributed to neutrophil accumulation. Furthermore, an LTB4‐inflammasome axis contributed to the expression of chemotactic molecules involved in high‐fat diet‐induced macrophage infiltration into WAT. We have identified previously unappreciated roles for neutrophils in the development of adipose tissue inflammation: robust IL‐1β production and infiltration of macrophages to initiate chronic inflammation.—Watanabe, Y., Nagai, Y., Honda, H., Okamoto, N., Yanagibashi, T., Ogasawara, M., Yamamoto, S., Imamura, R., Takasaki, I., Hara, H., Sasahara, M., Arita, M., Hida, S., Taniguchi, S., Suda, T., Takatsu, K. Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation. FASEB J. 33, 11821‐11835 (2019). www.fasebj.org