Shape Memory Polymers Based on Naturally-Occurring Bile Acids
Shape Memory Polymers Based on Naturally-Occurring Bile Acids
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DOI：
10.1021/ma901090r
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发表时间：
2009-09
期刊：
影响因子：
5.5
通讯作者：
J. Gautrot;Xinxia Zhu
中科院分区：
文献类型：
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作者：
J. Gautrot;Xinxia Zhu
天然存在的胆汁酸是新一代生物材料的理想结构单元，显示出低全身毒性和工程性质。在此，我们报告的胆汁酸基聚酯的合成使用熵驱动开环易位聚合（ED-ROMP）和所得聚合物的结构表征。合成的材料显示出高分子量（Mn高于100000），这是ED-ROMP的典型特征。通过动态力学分析（DMA）和热机械循环研究了这些胆汁酸基聚酯（BAP）的力学和响应行为。虽然BAP是无定形热塑性塑料，但它们显示出典型的橡胶样弹性，具有可调的机械行为，接近体温的玻璃化转变，以及出色的形状记忆性能。通过在BAP的化学结构中引入微小的变化（酰胺键或额外的羟基），我们能够将材料的刚度、Tg和形状恢复温度与材料的弹性模量相关联。
Naturally occurring bile acids are ideal building blocks for a new generation of biomaterials displaying low systemic toxicity and engineered properties. Herein we report the synthesis of bile acid-based polyesters using entropy-driven ring-opening metathesis polymerization (ED-ROMP) and characterization of the structure of the resulting polymers. The materials synthesized display high molecular weights (Mn above 100000), typical of ED-ROMPs. The mechanical and responsive behavior of these bile acid-based polyesters (BAPs) is studied by dynamic mechanical analysis (DMA) and thermomechanical cycling. Although BAPs are amorphous thermoplastics, they display typical rubber-like elasticity with tunable mechanical behavior, glass transitions close to body temperature, and outstanding shape memory properties. By introducing small changes in the chemical structure of BAPs (amide bonds or additional hydroxyl groups), we were able to correlate the materials’ stiffness, their Tg and shape recovery temperature to th...