Central Nervous System Manifestations of COVID-19: A Critical Review and Proposed Research Agenda.
Central Nervous System Manifestations of COVID-19: A Critical Review and Proposed Research Agenda.
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DOI：
10.1017/s1355617721000345
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发表时间：
2022-03
影响因子：
2.6
通讯作者：
Bowers, Dawn
中科院分区：
文献类型：
--
作者：
Hewitt, Kelsey C.;Marra, David E.;Block, Cady;Cysique, Lucette A.;Drane, Daniel L.;Haddad, Michelle M.;Lojek, Emilia;McDonald, Carrie R.;Reyes, Anny;Eversole, Kara;Bowers, Dawn
2020年3月11日，世界卫生组织宣布新型病毒实体2019冠状病毒（COVID-19）爆发为全球大流行。这种病毒的特征及其短期和长期影响尚不清楚。本文的目的是对新出现的关于COVID-19及其对神经、神经精神和认知功能影响的文献进行批判性综述。通过检索PubMed、PubMed Central、Google Scholar和bioRxiv，对最近发表的关于COVID-19中枢神经系统（CNS）并发症的经验研究、病例研究和综述进行了批判性综述。在考虑了现有文献后，对被认为与临床和研究神经心理学家最相关的领域进行了综述，包括CNS表现、神经症状/综合征、神经影像学以及COVID-19感染的潜在长期影响。COVID-19曾被认为只是一种呼吸道病毒，但科学界和医学界已经意识到COVID-19对肾脏、血管和神经系统有更广泛的影响。认知缺陷的问题还没有得到很好的研究，但神经心理学家无疑将在未来几年发挥重要作用。
On March 11, 2020, the World Health Organization declared an outbreak of a new viral entity, coronavirus 2019 (COVID-19), to be a worldwide pandemic. The characteristics of this virus, as well as its short- and long-term implications, are not yet well understood. The objective of the current paper was to provide a critical review of the emerging literature on COVID-19 and its implications for neurological, neuropsychiatric, and cognitive functioning. A critical review of recently published empirical research, case studies, and reviews pertaining to central nervous system (CNS) complications of COVID-19 was conducted by searching PubMed, PubMed Central, Google Scholar, and bioRxiv. After considering the available literature, areas thought to be most pertinent to clinical and research neuropsychologists, including CNS manifestations, neurologic symptoms/syndromes, neuroimaging, and potential long-term implications of COVID-19 infection, were reviewed. Once thought to be merely a respiratory virus, the scientific and medical communities have realized COVID-19 to have broader effects on renal, vascular, and neurological body systems. The question of cognitive deficits is not yet well studied, but neuropsychologists will undoubtedly play an important role in the years to come.