Determining in vivo elasticity and viscosity with dynamic Scheimpflug imaging analysis in keratoconic and healthy eyes
Determining in vivo elasticity and viscosity with dynamic Scheimpflug imaging analysis in keratoconic and healthy eyes
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DOI：
10.1002/jbio.201500245
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发表时间：
2016-05-01
影响因子：
2.8
通讯作者：
Zheng, Yong-Ping
中科院分区：
文献类型：
--
作者：
Wang, Li-Ke;Tian, Lei;Zheng, Yong-Ping
本文提出了一种基于角膜可视化Scheimpflug技术（CorVis ST）的圆锥角膜弹性和粘性分析方法。提出了吹气力测量和角膜成像边界提取的方法。角膜的生物力学特性，描述为切线刚度系数（STSC）和能量吸收面积（A（吸收）），使用施加的空气吹压力与角膜位移的曲线来评估，以形成加载-卸载循环。25例圆锥角膜患者和34例健康对照受试者，眼内压（IOP）匹配，入组这项前瞻性研究。结果表明，正常组STSC和Aabsorbed的组内相关系数分别为0.941和0.878，圆锥角膜组分别为0.891和0.809。圆锥角膜组STSC和Aabsorbed值与对照组比较有显著性差异（均P < 0.001）。ROC曲线分析表明，STSC的曲线下面积为0.918，Aabsorbed的曲线下面积为0.894，对圆锥角膜有较好的预测准确性。我们的结果表明，这种新的分析方法可以用来表征角膜的生物力学性能。[图表]（a）通过定制设计的力检测系统测量CorVis ST的喷气力。(b)使用提出的成像分析从CorVis ST中提取角膜位移。(c)利用吹气力和角膜动态位移，提出了一种新的角膜生物力学参数-- S-TSC和A（吸收）的分析方法。
The paper presents a novel analysis method of corneal elasticity and viscosity based on corneal visualization Scheimpflug technology (CorVis ST) for keratoconus diagnosis. Methods for air puff force measurement and corneal imaging boundary extraction were proposed. Corneal biomechanical properties, described as tangent stiffness coefficient (STSC) and energy absorbed area (A(absorbed)), were assessed using the curves of the applied air puff force with corneal displacement to form a loading-unloading cycle. Twenty-five patients with keratoconus and 34 healthy control subjects, matched for intraocular pressure (IOP), were enrolled in this prospective study. The results showed that the intraclass correlation coefficients (ICC) of the STSC and Aabsorbed were 0.941 and 0.878 in Healthy group; and were 0.891 and 0.809 in Keratoconus group, respectively. Both STSC and Aabsorbed of keratoconus patients were significantly different from that of controls (both probability value P < 0.001). ROC curve analysis showed that the area under curve for STSC was 0.918 and for Aabsorbed was 0.894, which reached a good level of predictive accuracy for detecting keratoconus. Our results demonstrated that this new analysis method could be used to characterize the biomechanical properties of corneas.[GRAPHICS](a) The air puff force of CorVis ST was measured by a custom-designed force detection system. (b) Corneal displacement was extracted from CorVis ST using a proposed imaging analysis. (c) With the utilization of the air puff force and corneal dynamic displacement, an analysis method was developed to introduce new corneal biomechanical parameters - S-TSC and A(absorbed).