Mindfulness-based stress reduction as a novel treatment for interstitial cystitis/bladder pain syndrome: a randomized controlled trial
Mindfulness-based stress reduction as a novel treatment for interstitial cystitis/bladder pain syndrome: a randomized controlled trial
复制标题
DOI：
10.1007/s00192-016-3022-8
复制
发表时间：
2016-11-01
影响因子：
1.8
通讯作者：
Rogers, Rebecca G.
中科院分区：
文献类型：
--
作者：
Kanter, Gregory;Komesu, Yuko M.;Rogers, Rebecca G.
基于正念的减压（MBSR）是一种标准化的冥想计划，可能是间质性膀胱炎/膀胱疼痛综合征（IC/BPS）的有效治疗方法，这是一种因压力而加剧的疾病。本研究的目的是探讨MBSR是否能改善IC/BPS症状以及MSBR在IC/BPS女性患者中的可行性/可接受性。女性被随机分配到继续常规护理（UC）或8周MBSR课程+常规护理（MBSR）。参与者完成了基线和治疗后8周的问卷调查，包括O 'Leary-Sant症状问题指数（OSPI），视觉模拟疼痛量表（VAS），简明健康调查表（SF-12），女性性功能指数（FSFI）和疼痛自我效能问卷（PSEQ）。治疗后完成了总体缓解评估（GRA）。分析采用学生t检验、卡方检验和多变量方差分析（MANOVA），11名女性被随机分配到UC组，9名被随机分配到正念减压组，两组特征无差异。更多的MBSR参与者的症状在GRA上得到改善（8人中的7人[87.5%] vs 11人中的4人[36.4%]，p = 0.03）。MBSR组在OSPI总分（p = 0.0498）和问题评分（p = 0.036）方面表现出更大的改善; OSPI症状评分变化没有差异。与UC相比，MBSR的PSEQ评分改善（p = 0.035）。两组间VAS、SF-12和FSFI变化无差异。86%的MBSR参与者感到更有能力控制症状，所有参与者都计划继续MBSR。这项试验提供了初步证据，MBSR是一种有希望的IC/BPS的连续治疗。它的好处可能来自患者的赋权和科普症状的能力。
Mindfulness-based stress reduction (MBSR) is a standardized meditation program that may be an effective therapy for interstitial cystitis/bladder pain syndrome (IC/BPS), a condition exacerbated by stress. The aims of this study were to explore whether MBSR improved IC/BPS symptoms and the feasibility/acceptability of MSBR among women with IC/BPS.This randomized controlled trial included women with IC/BPS undergoing first- or second-line therapies. Women were randomized to continuation of usual care (UC) or an 8-week MBSR class + usual care (MBSR). Participants completed baseline and 8-week post-treatment questionnaires, including the O'Leary-Sant Symptom Problem Index (OSPI), the visual analog pain scale (VAS), the Short Form Health Survey (SF-12), the Female Sexual Function Index (FSFI), and the Pain Self-Efficacy Questionnaire (PSEQ). The Global Response Assessment (GRA) was completed post-treatment. Analyses were performed using Student's t test, Chi-squared, and MANOVA where appropriate.Eleven women were randomized to UC and 9 to MBSR, without differences in group characteristics. More MBSR participants' symptoms were improved on the GRA (7 out of 8 [87.5 %] vs 4 out of 11 [36.4 %], p = 0.03). The MBSR group showed greater improvement in the OSPI total (p = 0.0498) and problem scores (p = 0.036); the OSPI symptom score change did not differ. PSEQ scores improved in MBSR compared with UC (p = 0.035). VAS, SF-12, and FSFI change did not differ between groups. Eighty-six percent of MBSR participants felt more empowered to control symptoms, and all participants planned to continue MBSR.This trial provides initial evidence that MBSR is a promising adjunctive therapy for IC/BPS. Its benefit may arise from patients' empowerment and ability to cope with symptoms.