A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder
A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder
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DOI：
10.1002/da.20347
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发表时间：
2008-01-01
影响因子：
7.4
通讯作者：
Rauch, Scott L.
中科院分区：
文献类型：
--
作者：
Evans, Karleyton C.;Wright, Christopher I.;Rauch, Scott L.
使用愤怒或轻蔑的人类面部照片刺激的神经影像学研究表明，社交焦虑障碍（SAD）的杏仁核反应过度。我们试图确定一个愤怒的“示意性的脸”（简单的线条画）是否会引起SAD患者与健康对照（HC）受试者相比，杏仁核反应过度。愤怒，快乐和中性的示意性面孔被公开呈现给11个SAD和11个HC受试者的匹配队列进行被动观察，而脑功能磁共振成像信号在1.5特斯拉下测量。使用SPM 99中的随机效应模型进行逐体素分析。与HC受试者相比，SAD患者在紧张的杏仁核中表现出对愤怒与中性对比的夸大反应。SAD患者杏仁核对愤怒的示意性面孔反应过度的研究结果与早期神经影像学研究的结果一致，并说明了示意性面孔在精神疾病中探测杏仁核功能的潜在效用。图式面孔的一个潜在优势是，它们可以最大限度地减少与性别、年龄或种族效应有关的混淆。然而，在健康受试者中扩展了早期的发现，图式面孔似乎更有效地探测杏仁核对觉醒（愤怒与中性）的反应，而不是基于效价（愤怒与快乐）的对比。
Neuroimaging studies using angry or contemptuous human facial photographic stimuli have suggested amygdala hyper-responsivity in social anxiety disorder (SAD). We sought to determine if an angry "schematic face" (simple line drawing) would evoke exaggerated amygdalar responses in SAD patients compared with healthy control (HC) subjects. Angry, happy, and neutral schematic faces were overtly presented to matched cohorts of 11 SAD and 11 HC subjects for passive viewing, whereas brain functional magnetic resonance imaging signal was measured at 1.5 Tesla. Voxel-wise analyses were performed using a random effects model in SPM99. Compared with HC subjects, SAD patients exhibited exaggerated responses in the tight amygdala for the Angry versus Neutral contrast. The findings of exaggerated amygdala responses to angry schematic faces in SAD converge with results from earlier neuroimaging studies and illustrate the potential utility of schematic faces for probing amygdala function in psychiatric disorders. One prospective advantage of schematic faces is that they may minimize confounds related to gender, age, or race effects. However, extending earlier findings in healthy subjects, schematic faces appear more effective for probing amygdala responses to arousal-based (Angry versus Neutral) as opposed to valence-based (Angry versus Happy) contrasts.