SENSITIZATION TO THE PSYCHOMOTOR EFFECTS OF AMPHETAMINE AND MORPHINE-INDUCED BY FOOD RESTRICTION DEPENDS ON CORTICOSTERONE SECRETION
SENSITIZATION TO THE PSYCHOMOTOR EFFECTS OF AMPHETAMINE AND MORPHINE-INDUCED BY FOOD RESTRICTION DEPENDS ON CORTICOSTERONE SECRETION
复制标题
DOI：
10.1016/0006-8993(93)90526-s
复制
发表时间：
1993-05-21
期刊：
影响因子：
2.9
通讯作者：
SIMON, H
中科院分区：
文献类型：
--
作者：
DEROCHE, V;PIAZZA, PV;SIMON, H
食物限制已被证明可以增强对成瘾药物的行为敏感性。这种影响所涉及的生物因素在很大程度上是未知的。由于食物限制，除其他因素外，增加皮质酮分泌，这种激素的作用，食物限制的影响，对精神兴奋剂和阿片类药物的反应进行了研究。比较了食物限制对安非他明和吗啡诱导的自发活动的影响：（i）下丘脑-垂体-肾上腺轴完整的动物;（ii）通过肾上腺切除术抑制食物限制诱导的皮质酮分泌的动物，但从皮下植入物接受外源性皮质酮，其缓慢释放皮质酮，在20天内产生在正常生理范围内的稳定血浆水平。发现食物限制增强了对安非他明（1 mg/kg i. p.）和吗啡（lmg/kg i. p.）在下丘脑-垂体-肾上腺轴完整的动物中，但在内源性皮质酮分泌被消除的动物中则不然。这些结果表明，皮质酮分泌可能是食物限制放大安非他明和吗啡的行为反应的机制之一。由于已发现对成瘾药物的运动反应性增强经常与药物自我给药的脆弱性增强相关，因此这些发现指出糖皮质激素在药物滥用易感性中的作用。
Food restriction has been shown to enhance the behavioral sensitivity to addictive drugs. The biological factors involved in this effect are largely unknown. Since food restriction, among other factors, increases corticosterone secretion, the role of this hormone in the effects of food restriction on the response to psychostimulants and opioids was investigated. The effects of food restriction on amphetamine- and morphine-induced locomotor activity were compared in: (i) animals with an intact hypothalamo-pituitary-adrenal axis; (ii) animals in which food restriction-induced corticosterone secretion was suppressed by adrenalectomy, but which received exogenous corticosterone from a subcutaneous implant, which slowly releases corticosterone, producing a stable plasma level within the normal physiological range over a period of 20 days. It was found that food restriction enhanced sensitivity to the psychomotor effects of amphetamine (1 mg/kg i.p.) and morphine (1 mg/kg i.p.) in animals with an intact hypothalamo-pituitary-adrenal axis, but not in animals in which endogenous corticosterone secretion was eliminated. These results suggest that corticosterone secretion may be one of the mechanisms by which food restriction amplifies the behavioral responses to amphetamine and morphine. Since an enhanced locomotor reactivity to addictive drugs has been found to be frequently associated with an enhanced vulnerability to drug self-administration, these findings point to a role for glucocorticoids in the susceptibility to drug abuse.