Time predictability modulates pre-supplementary motor area neuronal activity
Time predictability modulates pre-supplementary motor area neuronal activity
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DOI：
10.1097/01.wnr.0000127347.87552.87
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发表时间：
2004-06-07
期刊：
影响因子：
1.7
通讯作者：
Burbaud, P
中科院分区：
文献类型：
--
作者：
Akkal, D;Escola, L;Burbaud, P
两个猴子在一个延迟的顺序运动任务，其中事件之间的时间间隔和延迟持续时间是固定的或可变的。在前辅助运动区（pre-SMA）记录单个单位神经元活动。在延迟期间，我们观察到在固定条件下活动（积聚模式）逐渐增加，但在可变条件下没有。在前一种情况下，猴子有机会估计持续时间，但在后一种情况下没有。因此，在前SMA中观察到的积聚模式可能代表先前作者基于功能成像数据提出的时间累积器系统的神经元基底。这样一个系统可以在时间信息的工作记忆中发挥关键作用。
Two monkeys were trained in a delayed sequential motor task in which the time interval between events and the delay duration were either fixed or variable. Single-unit neuronal activity was recorded in the pre-supplementary motor area (pre-SMA). During the delay, we observed a gradual increase in activity (build-up pattern) in the fixed but not in the variable condition. In the former but not in the latter, the monkey had the opportunity to estimate time duration. Consequently, the build-up pattern observed in the pre-SMA might represent the neuronal substrate of a time accumulator system proposed by previous authors on the basis of functional imaging data. Such a system could play a critical role in the working memory of temporal information.