Decreased excitability of leptin-sensitive anterior insula pyramidal neurons in a rat model of compulsive food demand.
Decreased excitability of leptin-sensitive anterior insula pyramidal neurons in a rat model of compulsive food demand.
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DOI：
10.1016/j.neuropharm.2022.108980
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发表时间：
2022-05-01
影响因子：
4.7
通讯作者：
Zorrilla, Eric
中科院分区：
文献类型：
--
作者：
Kirson, Dean;Bagsic, Samantha R. Spierling;Murphy, Jiayuan;Chang, Hang;Vlkolinsky, Roman N.;Pucci, Sarah;Prinzi, Julia A.;Williams, Casey Y.;Fang, Savannah;Roberto, Marisa P.;Zorrilla, Eric
关键词：
强迫性进食与暴饮暴食是一个重叠的结构，与物质滥用障碍有许多共同的特征。强迫性进食可能会影响数百万美国人;在某些情况下出现暴食症，超重/肥胖，以及尚未被诊断出患有公认的饮食失调症的个体。为了研究强迫性进食的行为和神经生物学基础，我们采用了一种已发表的啮齿动物模型，该模型使用周期性间歇性获得可口的饮食来开发一种自我强加的暴食-戒断周期。在这里，我们进一步验证了这种强迫性进食的雌性Wistar大鼠模型，通过行为经济学分析的透镜，并观察到需求强度，缺乏弹性和必要价值的增加，以及在灭绝过程中增加食物寻求。使用在前岛叶皮层，一个区域先前涉及在间歇性访问模型中调制强迫性进食的电生理记录，我们观察到锥体神经元的功能适应。在相同的神经元中，瘦素的应用导致了进一步的功能适应，这表明瘦素在调节与进食相关的皮层回路中的下丘脑外作用以前研究不足。总的来说，研究结果表明，瘦素可能通过一个可塑性皮层回路来调节与食物相关的动机或决策，该回路受到间歇性获得偏好饮食的影响。这些发现需要进一步研究强迫性进食行为的行为经济学是否会影响人类的进食障碍，以及这些行为中是否涉及瘦素敏感的前岛回路的翻译相关性。
Compulsive eating is an overlapping construct with binge eating and shares many characteristics with substance abuse disorders. Compulsive eating may impact millions of Americans; presenting in some cases of binge eating disorders, overweight/obesity, and among individuals who have not yet been diagnosed with a recognized eating disorder. To study the behavioral and neurobiological underpinnings of compulsive eating, we employ a published rodent model using cyclic intermittent access to a palatable diet to develop a self-imposed binge-withdrawal cycle. Here, we further validated this model of compulsive eating in female Wistar rats, through the lens of behavioral economic analyses, and observed heightened demand intensity, inelasticity and essential value as well as increased food-seeking during extinction. Using electrophysiological recordings in the anterior insular cortex, a region previously implicated in modulating compulsive-like eating in intermittent access models, we observed functional adaptations of pyramidal neurons. Within the same neurons, application of leptin led to further functional adaptations, suggesting a previously understudied, extrahypothalamic role of leptin in modulating feeding-related cortical circuits. Collectively, the findings suggest that leptin may modulate food-related motivation or decisionmaking via a plastic cortical circuit that is influenced by intermitted access to a preferred diet. These findings warrant further study for whether the behavioral economics of compulsive eating behavior can impact disordered eating outcomes in humans, and whether there is translational relevance of a leptin-sensitive anterior insular circuit implicated in these behaviors.
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DOI：
10.1111/add.13061
发表时间：
2015-12
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Abdolahi A;Williams GC;Benesch CG;Wang HZ;Spitzer EM;Scott BE;Block RC;van Wijngaarden E
通讯作者：
van Wijngaarden E
DOI：
10.1007/s40519-014-0173-9
发表时间：
2015-03
期刊：
Eating and weight disorders : EWD
影响因子：
--
作者：
Ágh T;Kovács G;Pawaskar M;Supina D;Inotai A;Vokó Z
通讯作者：
Vokó Z
影响因子：
5.3
作者：
Baver, Scott B.;Hope, Kevin;O'Connell, Kristen M. S.
通讯作者：
O'Connell, Kristen M. S.
影响因子：
4.2
作者：
BICKEL, WK;DEGRANDPRE, RJ;HIGGINS, ST
通讯作者：
HIGGINS, ST
影响因子：
4.4
作者：
Abdolahi, Amir;Williams, Geoffrey C.;van Wijngaarden, Edwin
通讯作者：
van Wijngaarden, Edwin