Cancer stem cells: constantly evolving and functionally heterogeneous therapeutic targets.
Cancer stem cells: constantly evolving and functionally heterogeneous therapeutic targets.
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DOI：
10.1158/0008-5472.can-14-0266
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发表时间：
2014-06-01
期刊：
影响因子：
11.2
通讯作者：
Tang DG
中科院分区：
文献类型：
--
作者：
Yang T;Rycaj K;Liu ZM;Tang DG
Elucidating the origin of and dynamic interrelationship between intratumoral cell subpopulations has clear clinical significance in helping understand the cellular basis of treatment response, therapeutic resistance, and tumor relapse. Cancer stem cells (CSC), together with clonal evolution driven by genetic alterations, generate cancer cell heterogeneity commonly observed in clinical samples. The 2013 Shanghai International Symposium on Cancer Stem Cells# brought together leaders in the field to highlight the most recent progress in phenotyping, characterizing, and targeting CSC and in elucidating the relationship between the cell-of-origin of cancer versus CSC. Discussions from the symposium emphasize the urgent need in developing novel therapeutics to target the constantly evolving CSC.
