CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense
CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense
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DOI：
10.1159/000444125
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发表时间：
2016-01-01
影响因子：
5.3
通讯作者：
Hartl, D.
中科院分区：
文献类型：
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作者：
Carevic, M.;Oez, H.;Hartl, D.
铜绿假单胞菌是引起囊性纤维化（CF）和其他肺部疾病如慢性阻塞性肺病（COPD）的关键机会致病菌。然而，调节抗铜绿假单胞菌免疫的肺宿主防御机制仍不完全清楚。在这里，我们证明，通过研究气道铜绿假单胞菌感染模型，在体内生物发光成像，中性粒细胞效应反应和人类气道样本，趋化因子受体CXCR1调节肺宿主防御铜绿假单胞菌。CXCR1通过调节活性氧和干扰Toll样受体5的表达来调节抗假单胞菌中性粒细胞反应。这些研究将CXCR1定义为一种新型的非经典趋化因子受体，其调节肺抗假单胞菌宿主防御，对CF、COPD和其他感染性肺病具有广泛意义。(C)2016 S. Karger AG，巴塞尔
Pseudomonas aeruginosa is a key opportunistic pathogen causing disease in cystic fibrosis (CF) and other lung diseases such as chronic obstructive pulmonary disease (COPD). However, the pulmonary host defense mechanisms regulating anti-P. aeruginosa immunity remain incompletely understood. Here we demonstrate, by studying an airway P. aeruginosa infection model, in vivo bioluminescence imaging, neutrophil effector responses and human airway samples, that the chemokine receptor CXCR1 regulates pulmonary host defense against P. aeruginosa. Mechanistically, CXCR1 regulates anti-Pseudomonas neutrophil responses through modulation of reactive oxygen species and interference with Toll-like receptor 5 expression. These studies define CXCR1 as a novel, noncanonical chemokine receptor that regulates pulmonary anti-Pseudomonas host defense with broad implications for CF, COPD and other infectious lung diseases. (C) 2016 S. Karger AG, Basel