Biomarkers of environmental tobacco smoke exposure.
Biomarkers of environmental tobacco smoke exposure.
复制标题
环境烟草烟雾暴露的生物标志物。
DOI：
10.1289/ehp.99107s2349
复制
发表时间：
1999-05
影响因子：
10.4
通讯作者：
中科院分区：
文献类型：
--
作者：
生物标志物对于量化人类暴露于环境烟草烟雾(ETS)和预测暴露于环境烟草烟雾(ETS)个人的潜在健康风险是可取的。已经提出了一些ETS的生物标记物。目前，在血液、唾液或尿液中测量的可替宁似乎是最特异和最敏感的生物标记物。在大量接触ETS的非吸烟者中，体内的可替宁水平主要来自烟草烟雾，可以极高的灵敏度进行测量，并反映出与机器决定的产量无关的各种类型卷烟的暴露。在持续暴露于ETS的条件下(即超过数小时或数天)，可替宁水平反映了对ETS其他成分的暴露。在不吸烟的儿童中，可替宁水平与一些与ETS相关的健康并发症的风险呈正相关，这支持了可替宁作为生物标志物的有效性。
Biomarkers are desirable for quantitating human exposure to environmental tobacco smoke (ETS) and for predicting potential health risks for exposed individuals. A number of biomarkers of ETS have been proposed. At present cotinine, measured in blood, saliva, or urine, appears to be the most specific and the most sensitive biomarker. In nonsmokers with significant exposure to ETS, cotinine levels in the body are derived primarily from tobacco smoke, can be measured with extremely high sensitivity, and reflect exposure to a variety of types of cigarettes independent of machine-determined yield. Under conditions of sustained exposure to ETS (i.e., over hours or days), cotinine levels reflect exposure to other components of ETS. Supporting the validity of cotinine as a biomarker, cotinine levels have been positively correlated to the risks of some ETS-related health complications in children who are not cigarette smokers.