Interim estimates of 2013/14 vaccine effectiveness against influenza A(H1N1) pdm09 from Canada's sentinel surveillance network, January 2014
Interim estimates of 2013/14 vaccine effectiveness against influenza A(H1N1) pdm09 from Canada's sentinel surveillance network, January 2014
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DOI：
10.2807/1560-7917.es2014.19.5.20690
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发表时间：
2014-02-06
期刊：
影响因子：
19
通讯作者：
Li, Y.
中科院分区：
文献类型：
--
作者：
Skowronski, D. M.;Chambers, C.;Li, Y.
到目前为止，加拿大2013/14年流感季节的特点是主要(90%)甲型H1N1流感pdm09活动。疫苗有效性(VE)于2014年1月由加拿大哨兵监测网络使用试验阴性病例对照设计进行评估。临时调整后的VE对由医生参加的实验室确认的甲型H1N1流感pdm09感染的影响为74%(95%CI：58-83)。相对于疫苗，A(H1N1)pdm09病毒在抗原性上相似，遗传上保存良好，大多数病毒在构成血凝素蛋白抗原位点的50个氨基酸中只显示了三个突变。
The 2013/14 influenza season to date in Canada has been characterised by predominant (90%) A(H1N1) pdm09 activity. Vaccine effectiveness (VE) was assessed in January 2014 by Canada's sentinel surveillance network using a test-negative case-control design. Interim adjusted-VE against medically-attended laboratory-confirmed influenza A(H1N1) pdm09 infection was 74% (95% CI: 58-83). Relative to vaccine, A(H1N1) pdm09 viruses were antigenically similar and genetically well conserved, with most showing just three mutations across the 50 amino acids comprising antigenic sites of the haemagglutinin protein.